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Mesolimbic dopamine and its neuromodulators in obesity and binge eating


Naef, L and Pitman, KA and Borgland, SL, Mesolimbic dopamine and its neuromodulators in obesity and binge eating, CNS spectrums pp. 1-10. ISSN 1092-8529 (2015) [Substantial Review]

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Obesity has reached epidemic prevalence, and much research has focused on homeostatic and nonhomeostatic mechanisms underlying overconsumption of food. Mesocorticolimbic circuitry, including dopamine neurons of the ventral tegmental area (VTA), is a key substrate for nonhomeostatic feeding. The goal of the present review is to compare changes in mesolimbic dopamine function in human obesity with diet-induced obesity in rodents. Additionally, we will review the literature to determine if dopamine signaling is altered with binge eating disorder in humans or binge eating modeled in rodents. Finally, we assess modulation of dopamine neurons by neuropeptides and peripheral peptidergic signals that occur with obesity or binge eating. We find that while decreased dopamine concentration is observed with obesity, there is inconsistency outside the human literature on the relationship between striatal D2 receptor expression and obesity. Finally, few studies have explored how orexigenic or anorexigenic peptides modulate dopamine neuronal activity or striatal dopamine in obese models. However, ghrelin modulation of dopamine neurons may be an important factor for driving binge feeding in rodents.

Item Details

Item Type:Substantial Review
Keywords:dopamine, binge eating, obesity, high fat, diet
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Pitman, KA (Ms Kimberley Pitman)
ID Code:104775
Year Published:2015
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-19
Last Modified:2015-11-23
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