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Changes in mu-opioid receptor expression and function in the mesolimbic system after long-term access to a palatable diet

Citation

Pitman, KA and Borgland, SL, Changes in mu-opioid receptor expression and function in the mesolimbic system after long-term access to a palatable diet, Pharmacology & therapeutics, 154 pp. 110-9. ISSN 0163-7258 (2015) [Substantial Review]


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DOI: doi:10.1016/j.pharmthera.2015.07.005

Abstract

The incidence of obesity in both adults and children is rising. In order to develop effective treatments for obesity, it is important to understand how diet can induce changes in the brain that could promote excessive intake of high-calorie foods and alter the efficacy of therapeutic targets. The mu-opioid receptor is involved in regulating the motivation for and hedonic reaction to food. Here, we review the literature examining changes in the expression and function of mu-opioid receptors in the mesolimbic system of rodents after extended access to a high-fat diet. We also review how maternal diet can induce long-term changes in the expression or function of mu-opioid receptors in the mesolimbic system of offspring. Understanding the behavioural and therapeutic implications of these changes requires further study.

Item Details

Item Type:Substantial Review
Keywords:Obesity, mu-opioid receptor, dopamine
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Pitman, KA (Ms Kimberley Pitman)
ID Code:104774
Year Published:2015
Web of Science® Times Cited:8
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-19
Last Modified:2015-11-27
Downloads:0

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