eCite Digital Repository
Changes in mu-opioid receptor expression and function in the mesolimbic system after long-term access to a palatable diet
Citation
Pitman, KA and Borgland, SL, Changes in mu-opioid receptor expression and function in the mesolimbic system after long-term access to a palatable diet, Pharmacology & therapeutics, 154 pp. 110-9. ISSN 0163-7258 (2015) [Substantial Review]
 | PDF Pending copyright assessment - Request a copy 440Kb |
DOI: doi:10.1016/j.pharmthera.2015.07.005
Abstract
The incidence of obesity in both adults and children is rising. In order to develop effective treatments for obesity,
it is important to understand how diet can induce changes in the brain that could promote excessive intake of
high-calorie foods and alter the efficacy of therapeutic targets. The mu-opioid receptor is involved in regulating
the motivation for and hedonic reaction to food. Here, we review the literature examining changes in the expression
and function of mu-opioid receptors in the mesolimbic system of rodents after extended access to a high-fat
diet. We also review how maternal diet can induce long-term changes in the expression or function of mu-opioid
receptors in the mesolimbic system of offspring. Understanding the behavioural and therapeutic implications of
these changes requires further study.
Item Details
| Item Type: | Substantial Review |
|---|---|
| Keywords: | Obesity, mu-opioid receptor, dopamine |
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Neurosciences |
| Research Field: | Central nervous system |
| Objective Division: | Health |
| Objective Group: | Other health |
| Objective Field: | Other health not elsewhere classified |
| UTAS Author: | Pitman, KA (Dr Kimberley Pitman) |
| ID Code: | 104774 |
| Year Published: | 2015 |
| Web of Science® Times Cited: | 13 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2015-11-19 |
| Last Modified: | 2015-11-27 |
| Downloads: | 0 |
Repository Staff Only: item control page