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Palmitoylation of d-catenin by DHHC5 mediates activity-induced synapse plasticity
Citation
Brigidi, GS and Sun, Y and Beccano-Kelly, D and Pitman, K and Mobasser, M and Borgland, SL and Milnerwood, AJ and Bamji, SX, Palmitoylation of d-catenin by DHHC5 mediates activity-induced synapse plasticity, Nature Neuroscience, 17, (4) pp. 522-32. ISSN 1097-6256 (2014) [Refereed Article]
Copyright Statement
© 2014 Nature America
DOI: doi:10.1038/nn.3657
Abstract
Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms
that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse
morphology and efficacy remain unknown. We demonstrate that the intracellular cadherin binding protein d-catenin
is transiently palmitoylated by DHHC5 after enhanced synaptic activity and that palmitoylation increases d-catenin–cadherin
interactions at synapses. Both the palmitoylation of d-catenin and its binding to cadherin are required for activity-induced
stabilization of N-cadherin at synapses and the enlargement of postsynaptic spines, as well as the insertion of GluA1 and GluA2
subunits into the synaptic membrane and the concomitant increase in miniature excitatory postsynaptic current amplitude.
Notably, context-dependent fear conditioning in mice resulted in increased d-catenin palmitoylation, as well as increased
d-catenin–cadherin associations at hippocampal synapses. Together these findings suggest a role for palmitoylated d-catenin
in coordinating activity-dependent changes in synaptic adhesion molecules, synapse structure and receptor localization that are
involved in memory formation.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | synaptic plasticity |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Central nervous system |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the biological sciences |
UTAS Author: | Pitman, K (Ms Kimberley Pitman) |
ID Code: | 104773 |
Year Published: | 2014 |
Web of Science® Times Cited: | 70 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2015-11-19 |
Last Modified: | 2017-11-06 |
Downloads: | 0 |
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