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Polyphenol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturational profile


Delvecchio, FR and Vadrucci, E and Cavalcanti, E and De Santis, S and Kunde, D and Vacca, M and Myers, J and Allen, F and Bianco, G and Huang, AY and Monsurro, V and Santino, A and Chieppa, M, Polyphenol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturational profile, European Journal of Immunology, 45, (9) pp. 2638-2649. ISSN 0014-2980 (2015) [Refereed Article]

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Copyright 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

DOI: doi:10.1002/eji.201545679


Currently little is known as to how nutritionally derived compounds may affect dendritic cell (DC) maturation and potentially prevent inappropriate inflammatory responses that are characteristic of chronic inflammatory syndromes. Previous observations have demonstrated that two polyphenols quercetin and piperine delivered through reconstituted oil bodies (ROBs-QP) can influence DC maturation in response to LPS leading to a modulated inflammatory response. In the present study, we examined the molecular effects of ROBs-QP exposure on DC differentiation in mice and identified a unique molecular signature in response to LPS administration that potentially modulates DC maturation and activity in inflammatory conditions. Following LPS administration, ROBsQP-exposed DCs expressed an altered molecular profile as compared with control DCs, including cytokine and chemokine production, chemokine receptor repertoire, and antigen presentation ability. In vivo ROBs-QP administration suppresses antigen-specific T-cell division in the draining lymph nodes resulting from a reduced ability to create stable immunological synapse. Our data demonstrate that polyphenols exposure can drive DCs toward a new anti-inflammatory molecular profile capable of dampening the inflammatory response, highlighting their potential as complementary nutritional approaches in the treatment of chronic inflammatory syndromes.

Item Details

Item Type:Refereed Article
Keywords:antigen presentation, dendritic cells, inflammation
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Kunde, D (Dr Dale Kunde)
ID Code:104655
Year Published:2015
Web of Science® Times Cited:25
Deposited By:Health Sciences
Deposited On:2015-11-18
Last Modified:2017-11-29

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