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Determination of acidity constants of sparingly soluble drugs in aqueous solution by the internal standard capillary electrophoresis method

Citation

Cabot, JM and Fuguet, E and Roses, M, Determination of acidity constants of sparingly soluble drugs in aqueous solution by the internal standard capillary electrophoresis method, Electrophoresis, 35, (24) pp. 3564-3569. ISSN 0173-0835 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

DOI: doi:10.1002/elps.201400353

Abstract

A set of 33 drugs with different solubilities, ranging from soluble to very insoluble, has been chosen in order to evaluate the performance of the internal standard CE method to determine acidity constants of compounds with limited solubility. The set of drugs tested in this work has been chosen as a function of their intrinsic solubility. For the most insoluble compounds, several analytical conditions to overcome the insolubility in aqueous buffers have been tested. This paper assesses the compound solubility limits for the IS-CE method in aqueous pKa determinations, and also compares the determined pKas with the results from the literature data obtained by other methods. It is proved that IS-CE method determines acidity constants of sparingly soluble drugs in aqueous media (compounds with logS down to around –6), whereas other reference methods require the use of aqueous–organic solvent buffers and extrapolation procedures to obtain the aqueous pKa for the same compounds.

Item Details

Item Type:Refereed Article
Keywords:pKa, electrophoresis, physico-chemical properties, low solubility
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Analytical Spectrometry
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Mathematical Sciences
Author:Cabot, JM (Dr Joan Cabot Canyelles)
ID Code:104640
Year Published:2014
Web of Science® Times Cited:10
Deposited By:Chemistry
Deposited On:2015-11-17
Last Modified:2017-11-29
Downloads:0

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