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Determination of acidity constants by the capillary electrophoresis internal standard method. IV. Polyprotic compounds

Citation

Cabot, JM and Fuguet, E and Rafols, C and Roses, M, Determination of acidity constants by the capillary electrophoresis internal standard method. IV. Polyprotic compounds, Journal of Chromatography A, 1279 pp. 108-116. ISSN 0021-9673 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 Elsevier B.V.

DOI: doi:10.1016/j.chroma.2013.01.018

Abstract

The IS-CE method is developed for pKa determination of polyprotic compounds. In this method, the internal standard (IS) and the polyprotic test compound are injected into the capillary electrophoresis (CE) system in buffers with appropriate pH. The pH of the buffers is not externally measured, but determined inside the capillary from the mobilities of the internal standards. Then the pKa values of the polyprotic compounds are obtained by fitting its mobilities to the in situ pH values. The method is faster than the classical CE method (a diprotic compound can be done in less than 15 min), and also than other methods like potentiometric and spectrophotometric titrations. The method has been successfully applied to 20 polyprotic test compounds of different chemical nature, including compounds with extreme or very close pKa values.

Item Details

Item Type:Refereed Article
Keywords:pKa, electrophoresis, physico-chemical properties
Research Division:Chemical Sciences
Research Group:Analytical Chemistry
Research Field:Analytical Spectrometry
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Mathematical Sciences
Author:Cabot, JM (Dr Joan Cabot Canyelles)
ID Code:104638
Year Published:2013
Web of Science® Times Cited:12
Deposited By:Chemistry
Deposited On:2015-11-17
Last Modified:2017-10-29
Downloads:0

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