Antony, B and Venn, A and Cicuttini, F and March, L and Blizzard, L and Dwyer, T and Cross, M and Jones, G and Ding, C, Association of body composition and hormonal and inflammatory factors with tibial cartilage volume and sex difference in cartilage volume in young adults, Arthritis Care & Research, 68, (4) pp. 517-525. ISSN 2151-464X (2016) [Refereed Article]
Copyright 2015 American College of Rheumatology
Objective To describe the associations between body composition, hormonal and inflammatory factors measured 5 years prior and tibial cartilage volume in young adults and to explore if these factors contribute to the sex difference in tibial cartilage volume.
Methods: Subjects broadly representative of the young adult Australian population (n = 328, aged 31-41 years, female 47.3%) were selected. They underwent T1-weighted fat-suppressed magnetic resonance imaging (MRI) of their knees. Tibial cartilage volume was measured from MRI. Sex hormone binding globulin (SHGB) and testosterone in a subset of females and C-reactive protein (CRP) and fibrinogen in both sexes were measured 5 years prior. Body mass index (BMI), fat mass and lean mass were calculated from height, weight and skinfolds.
Results: In multivariable analyses, correlates of tibial cartilage volume included lean body mass (β = 26.4 mm3; 95% confidence interval [95% CI] 13.6, 39.1), fat mass (β = −11.8 mm3; 95% CI −22.2, −1.4), and fibrinogen (β = − 146.4 mm3; 95% CI −276.4, −16.4), but not BMI, testosterone, or CRP level. In women, SHBG was positively associated with tibial cartilage volume (β = 0.67 mm3; 95% CI 0.14, 1.20) and Free Androgen Index was negatively associated with lateral tibial cartilage volume (β = −0.04 mm3; 95% CI −0.07, 0.00). Men had 13% more tibial cartilage volume (500 mm3) than women. The magnitude of this association decreased by 38%, 20%, and 37% after adjustment for lean body mass, fat mass, and fibrinogen, respectively.
Conclusion: Body composition, sex hormones and fibrinogen correlate with knee cartilage volume in young adult life. Sex difference in knee cartilage volume is contributed largely by variations in body composition and/or fibrinogen.
|Item Type:||Refereed Article|
|Keywords:||body composition, sex hormones, cartilage volume, sex difference, inflammatory markers|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|UTAS Author:||Antony, B (Dr Benny Eathakkattu Antony)|
|UTAS Author:||Venn, A (Professor Alison Venn)|
|UTAS Author:||Blizzard, L (Professor Leigh Blizzard)|
|UTAS Author:||Jones, G (Professor Graeme Jones)|
|UTAS Author:||Ding, C (Professor Chang-Hai Ding)|
|Year Published:||2016 (online first 2015)|
|Web of Science® Times Cited:||3|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||73 View Download Statistics|
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