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Association of body composition and hormonal and inflammatory factors with tibial cartilage volume and sex difference in cartilage volume in young adults

Citation

Antony, B and Venn, A and Cicuttini, F and March, L and Blizzard, L and Dwyer, T and Cross, M and Jones, G and Ding, C, Association of body composition and hormonal and inflammatory factors with tibial cartilage volume and sex difference in cartilage volume in young adults, Arthritis Care & Research, 68, (4) pp. 517-525. ISSN 2151-464X (2016) [Refereed Article]


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Copyright Statement

Copyright 2015 American College of Rheumatology

DOI: doi:10.1002/acr.22715

Abstract

Objective To describe the associations between body composition, hormonal and inflammatory factors measured 5 years prior and tibial cartilage volume in young adults and to explore if these factors contribute to the sex difference in tibial cartilage volume.

Methods: Subjects broadly representative of the young adult Australian population (n = 328, aged 31-41 years, female 47.3%) were selected. They underwent T1-weighted fat-suppressed magnetic resonance imaging (MRI) of their knees. Tibial cartilage volume was measured from MRI. Sex hormone binding globulin (SHGB) and testosterone in a subset of females and C-reactive protein (CRP) and fibrinogen in both sexes were measured 5 years prior. Body mass index (BMI), fat mass and lean mass were calculated from height, weight and skinfolds.

Results: In multivariable analyses, correlates of tibial cartilage volume included lean body mass (β = 26.4 mm3; 95% confidence interval [95% CI] 13.6, 39.1), fat mass (β = −11.8 mm3; 95% CI −22.2, −1.4), and fibrinogen (β = − 146.4 mm3; 95% CI −276.4, −16.4), but not BMI, testosterone, or CRP level. In women, SHBG was positively associated with tibial cartilage volume (β = 0.67 mm3; 95% CI 0.14, 1.20) and Free Androgen Index was negatively associated with lateral tibial cartilage volume (β = −0.04 mm3; 95% CI −0.07, 0.00). Men had 13% more tibial cartilage volume (500 mm3) than women. The magnitude of this association decreased by 38%, 20%, and 37% after adjustment for lean body mass, fat mass, and fibrinogen, respectively.

Conclusion: Body composition, sex hormones and fibrinogen correlate with knee cartilage volume in young adult life. Sex difference in knee cartilage volume is contributed largely by variations in body composition and/or fibrinogen.

Item Details

Item Type:Refereed Article
Keywords:body composition, sex hormones, cartilage volume, sex difference, inflammatory markers
Research Division:Medical and Health Sciences
Research Group:Clinical Sciences
Research Field:Rheumatology and Arthritis
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Skeletal System and Disorders (incl. Arthritis)
Author:Antony, B (Dr Benny Eathakkattu Antony)
Author:Venn, A (Professor Alison Venn)
Author:Blizzard, L (Professor Leigh Blizzard)
Author:Jones, G (Professor Graeme Jones)
Author:Ding, C (Professor Chang-Hai Ding)
ID Code:104630
Year Published:2016 (online first 2015)
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-17
Last Modified:2018-04-26
Downloads:65 View Download Statistics

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