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Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease


Venigalla, M and Sonego, S and Gyengesi, E and Sharman, MJ and Munch, G, Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease, Neurochemistry International, 95 pp. 63-74. ISSN 0197-0186 (2016) [Refereed Article]

Copyright Statement

Copyright 2015 Elsevier Ltd.

DOI: doi:10.1016/j.neuint.2015.10.011


Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by deposition of amyloid plaques and neurofibrillary tangles, as well as microglial and astroglial activation, and, finally, leading to neuronal dysfunction and death. Current treatments for AD primarily focus on enhancement of cholinergic transmission. However, these treatments are only symptomatic, and no disease-modifying drug is available for the treatment of AD patients. This review will provide an overview of the antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of a variety of nutraceuticals including curcumin, apigenin, docosahexaenoic acid, epigallocatechin gallate, α-lipoic acid and resveratrol and their potential for AD prevention and treatment. We suggest that therapeutic use of these compounds might lead to a safe strategy to delay the onset of AD or slow down its progression. The continuing investigation of the potential of these substances is necessary as they are promising compounds to yield a possible remedy for this pervasive disease.

Item Details

Item Type:Refereed Article
Keywords:Alzheimer’s disease, curcumin, apigenin, fish oil, green tea, lipoic acid, neuroinflammation
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Evaluation of health and support services
Objective Field:Evaluation of health and support services not elsewhere classified
UTAS Author:Sharman, MJ (Dr Matt Sharman)
ID Code:104592
Year Published:2016 (online first 2015)
Web of Science® Times Cited:106
Deposited By:Health Sciences
Deposited On:2015-11-16
Last Modified:2017-11-16

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