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Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease
Citation
Venigalla, M and Sonego, S and Gyengesi, E and Sharman, MJ and Munch, G, Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease, Neurochemistry International, 95 pp. 63-74. ISSN 0197-0186 (2016) [Refereed Article]
Copyright Statement
Copyright 2015 Elsevier Ltd.
DOI: doi:10.1016/j.neuint.2015.10.011
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, characterized by deposition of amyloid plaques and neurofibrillary tangles, as well as microglial and astroglial activation, and, finally, leading to neuronal dysfunction and death. Current treatments for AD primarily focus on enhancement of cholinergic transmission. However, these treatments are only symptomatic, and no disease-modifying drug is available for the treatment of AD patients. This review will provide an overview of the antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of a variety of nutraceuticals including curcumin, apigenin, docosahexaenoic acid, epigallocatechin gallate, α-lipoic acid and resveratrol and their potential for AD prevention and treatment. We suggest that therapeutic use of these compounds might lead to a safe strategy to delay the onset of AD or slow down its progression. The continuing investigation of the potential of these substances is necessary as they are promising compounds to yield a possible remedy for this pervasive disease.
Item Details
Item Type: | Refereed Article |
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Keywords: | Alzheimer’s disease, curcumin, apigenin, fish oil, green tea, lipoic acid, neuroinflammation |
Research Division: | Biomedical and Clinical Sciences |
Research Group: | Neurosciences |
Research Field: | Neurosciences not elsewhere classified |
Objective Division: | Health |
Objective Group: | Evaluation of health and support services |
Objective Field: | Evaluation of health and support services not elsewhere classified |
UTAS Author: | Sharman, MJ (Dr Matt Sharman) |
ID Code: | 104592 |
Year Published: | 2016 (online first 2015) |
Web of Science® Times Cited: | 99 |
Deposited By: | Health Sciences |
Deposited On: | 2015-11-16 |
Last Modified: | 2017-11-16 |
Downloads: | 0 |
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