Kerestes, R and Phal, PM and Stewart, C and Moffat, BA and Salinas, S and Cox, KL and Ellis, KA and Cyarto, EV and Ames, D and Martins, RN and Masters, CL and Rowe, CC and Sharman, MJ and Salvado, O and Szoeke, C and Lai, M and Lautenschlager, NT and Desmond, PM, Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease, British Journal of Psychiatry Open, 1, (2) pp. 139-148. ISSN 2044-6055 (2015) [Refereed Article]
Copyright 2015 The Royal College of Psychiatrists Licensed under Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) https://creativecommons.org/licenses/by-nc-nd/3.0/deed.en_GB
Background: Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns.
Aims: To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE ε4) allele.
Method: Participants were 22 SMC carrying the APOE ε4 allele (ε4+; mean age 72.18 years) and 58 SMC non-carriers (ε4–; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored.
Results: ε4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC–SMA connectivity.
Conclusions: The results provide the first evidence that ε4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.
|Item Type:||Refereed Article|
|Keywords:||APOE4, Alzheimer's disease, MRI|
|Research Division:||Medical and Health Sciences|
|Research Field:||Neurosciences not elsewhere classified|
|Objective Group:||Public Health (excl. Specific Population Health)|
|Objective Field:||Public Health (excl. Specific Population Health) not elsewhere classified|
|Author:||Sharman, MJ (Dr Matt Sharman)|
|Funding Support:||National Health and Medical Research Council (APP1005942)|
|Deposited By:||Health Sciences|
|Downloads:||46 View Download Statistics|
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