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Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease


Kerestes, R and Phal, PM and Stewart, C and Moffat, BA and Salinas, S and Cox, KL and Ellis, KA and Cyarto, EV and Ames, D and Martins, RN and Masters, CL and Rowe, CC and Sharman, MJ and Salvado, O and Szoeke, C and Lai, M and Lautenschlager, NT and Desmond, PM, Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease, British Journal of Psychiatry Open, 1, (2) pp. 139-148. ISSN 2044-6055 (2015) [Refereed Article]


Copyright Statement

Copyright 2015 The Royal College of Psychiatrists Licensed under Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)

DOI: doi:10.1192/bjpo.bp.115.001339


Background: Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns.

Aims: To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE ε4) allele.

Method: Participants were 22 SMC carrying the APOE ε4 allele (ε4+; mean age 72.18 years) and 58 SMC non-carriers (ε4–; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored.

Results: ε4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC–SMA connectivity.

Conclusions: The results provide the first evidence that ε4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.

Item Details

Item Type:Refereed Article
Keywords:APOE4, Alzheimer's disease, MRI
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Sharman, MJ (Dr Matt Sharman)
ID Code:104591
Year Published:2015
Funding Support:National Health and Medical Research Council (APP1005942)
Deposited By:Health Sciences
Deposited On:2015-11-16
Last Modified:2017-11-03
Downloads:185 View Download Statistics

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