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Calcium oxalates grown in human urine under different batch conditions


Walton, RC and Kavanagh, JP and Heywood, BR and ROA, PN, Calcium oxalates grown in human urine under different batch conditions, Journal of Crystal Growth, 284, (3-4) pp. 517-529. ISSN 0022-0248 (2004) [Refereed Article]

DOI: doi:10.1016/j.jcrysgro.2005.06.057


Calcium oxalate (CaOx) crystallisation in solution is often studied as it is the major crystalline phase in kidney stones, and as such contributes to a large proportion of pathological mineralisation. A variety of different methods are used to produce CaOx in urine, particularly with the goal of investigating mineral/organic interactions. Interpretation of growth phenomena in these studies often neglects the methodological differences, which are not always trivial. CaOx was grown simultaneously from a single pool of urine using six different protocols comparable to those found in the literature. The variations between the CaOx populations generated was great, with CaOx trihydrate detected as the most common hydromorph in two of the methods used, even though it is usually discounted in stone research. Crystal morphologies, density, particle size and surface area varied in all the methods tested, and a common technique used to remove organic matter from the crystal surface resulted in total phase transformation in one of the crystal populations. In conclusion, inter-assay comparisons of CaOx product are likely to be meaningless unless strict protocols are adhered to. Results indicate that certain crystalline properties considered relevant to stone formation may actually be a symptom of the experimental conditions.

Item Details

Item Type:Refereed Article
Keywords:biocrystallization, crystal morphology, growth models, calcium oxalate
Research Division:Chemical Sciences
Research Group:Macromolecular and materials chemistry
Research Field:Structure and dynamics of materials
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Heywood, BR (Professor Brigid Heywood)
ID Code:104469
Year Published:2004
Web of Science® Times Cited:19
Deposited By:Research Division
Deposited On:2015-11-12
Last Modified:2015-11-12

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