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Crystal assembly: The application of high affinity ligands and habit modification
Citation
Blagden, N and Heywood, BR, Crystal assembly: The application of high affinity ligands and habit modification, Crystal Growth and Design, 3, (2) pp. 167-173. ISSN 1528-7483 (2003) [Refereed Article]
Copyright Statement
© 2003 American Chemical Society
Abstract
Streptavidin-biotin was found to induce the aggregation of micrometer-sized calcite particles, and the optimum ligand-receptor surface tagging condition was found when monolayer coverage of the sample by the adsorbed ligand-receptor components was reduced to 80% coverage. The role of crystallography in the agglomeration process induced by the presence of surface-adsorbed ligand-receptor was also examined. This was achieved by using calcite exhibiting three different crystal habits: rhombohedral, hexagonal spindles, and triangular plates. The latter two habits express faces generated by anionic templates, and the topology of agglomerates suggests that the carboxyl group of the biotin and the streptavidin interacting with these surfaces generated a local variation in crystal packing. This was accounted for by simply relating the preferential interaction between the modified surface of the crystal and the high-affinity ligand complex on the functionality of additives used to template surfaces during crystal growth.
Item Details
Item Type: | Refereed Article |
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Keywords: | anion, biotin, calcium carbonate, ligand, receptor, streptavidin, binding affinity, chemical modification, chemical structure, crystal structure, crystallization |
Research Division: | Chemical Sciences |
Research Group: | Macromolecular and materials chemistry |
Research Field: | Structure and dynamics of materials |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the chemical sciences |
UTAS Author: | Heywood, BR (Professor Brigid Heywood) |
ID Code: | 104464 |
Year Published: | 2003 |
Web of Science® Times Cited: | 5 |
Deposited By: | Research Division |
Deposited On: | 2015-11-12 |
Last Modified: | 2015-12-22 |
Downloads: | 0 |
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