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Influence of monosaccharides and related molecules on the morphology of hydroxyapatite
Citation
Walsh, D and Kingston, JL and Heywood, BR and Mann, S, Influence of monosaccharides and related molecules on the morphology of hydroxyapatite, Journal of Crystal Growth, 133, (1-2) pp. 1-12. ISSN 0022-0248 (1993) [Refereed Article]
DOI: doi:10.1016/0022-0248(93)90097-G
Abstract
The influence of monosaccharides and related molecules on the crystal morphology of hydroxyapatite (HAP) precipitated from chloride-containing supersaturated solutions has been studied by transmission electron microscopy. Pulse addition of aliquots of CaCl2 to Na2HPO4 solutions resulted in the formation of plate-like HAP crystals. In contrast, the presence of the monosaccharides D-glucose, D-galactose, D-mannose, glucuronic acid, N-acetyl glucosamine and D-fructose (phosphate:additive = 6:1) induced the precipitation of needle-shaped HAP crystals elongated along the c-axis. Other molecules, such as sorbitol and 1,2-butanediol, also showed this morphological effect. The order of decreasing aspect ratios was; sorbitol = 1,2-butanediol (25:1)> fructose (20:1)> glucose = galactose = mannose = glucuronic acid = N-acetyl glucosamine (10:1). Expression of the needle-like morphology is discussed in terms of kinetic factors involving nucleation and growth. The former is dependent on the exclusion of Cl- from HAP nuclei due to additive interactions with an amorphous calcium phosphate precursor phase. The latter is related to the strength of additive binding with the subsequent development of {100} HAP crystal faces.
Item Details
Item Type: | Refereed Article |
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Keywords: | additive binding, crystal morphology, hydroxyapatite, kinetic factors, onosaccharides |
Research Division: | Biological Sciences |
Research Group: | Biochemistry and cell biology |
Research Field: | Structural biology (incl. macromolecular modelling) |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding knowledge |
Objective Field: | Expanding knowledge in the biological sciences |
UTAS Author: | Heywood, BR (Professor Brigid Heywood) |
ID Code: | 104429 |
Year Published: | 1993 |
Web of Science® Times Cited: | 89 |
Deposited By: | Research Division |
Deposited On: | 2015-11-11 |
Last Modified: | 2015-11-12 |
Downloads: | 0 |
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