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Influence of monosaccharides and related molecules on the morphology of hydroxyapatite


Walsh, D and Kingston, JL and Heywood, BR and Mann, S, Influence of monosaccharides and related molecules on the morphology of hydroxyapatite, Journal of Crystal Growth, 133, (1-2) pp. 1-12. ISSN 0022-0248 (1993) [Refereed Article]

DOI: doi:10.1016/0022-0248(93)90097-G


The influence of monosaccharides and related molecules on the crystal morphology of hydroxyapatite (HAP) precipitated from chloride-containing supersaturated solutions has been studied by transmission electron microscopy. Pulse addition of aliquots of CaCl2 to Na2HPO4 solutions resulted in the formation of plate-like HAP crystals. In contrast, the presence of the monosaccharides D-glucose, D-galactose, D-mannose, glucuronic acid, N-acetyl glucosamine and D-fructose (phosphate:additive = 6:1) induced the precipitation of needle-shaped HAP crystals elongated along the c-axis. Other molecules, such as sorbitol and 1,2-butanediol, also showed this morphological effect. The order of decreasing aspect ratios was; sorbitol = 1,2-butanediol (25:1)> fructose (20:1)> glucose = galactose = mannose = glucuronic acid = N-acetyl glucosamine (10:1). Expression of the needle-like morphology is discussed in terms of kinetic factors involving nucleation and growth. The former is dependent on the exclusion of Cl- from HAP nuclei due to additive interactions with an amorphous calcium phosphate precursor phase. The latter is related to the strength of additive binding with the subsequent development of {100} HAP crystal faces.

Item Details

Item Type:Refereed Article
Keywords:additive binding, crystal morphology, hydroxyapatite, kinetic factors, onosaccharides
Research Division:Biological Sciences
Research Group:Biochemistry and cell biology
Research Field:Structural biology (incl. macromolecular modelling)
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Heywood, BR (Professor Brigid Heywood)
ID Code:104429
Year Published:1993
Web of Science® Times Cited:91
Deposited By:Research Division
Deposited On:2015-11-11
Last Modified:2015-11-12

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