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Organ-specific crystalline structures of ferritin cores in β-thalassemia/hemoglobin E

journal contribution
posted on 2023-05-18, 14:15 authored by St Pierre, TG, Tran, KC, Webb, J, Macey, DJ, Heywood, BR, Sparks, NH, Wade, VJ, Manna, S, Pootrakul, P
The cores of ferritins isolated from different organs of human subjects with β-thalassemia/hemoglobin E (β-thal/HbE) disease have different size distributions and crystallinities depending on the source organ. These patients have not been treated by hypertransfusion regimen or iron chelation therapy. β-Thal/HbE spleens and livers yield ferritin cores which are less crystalline than those isolated from normal spleens and livers, reflecting the more rapid deposition of iron in the diseased state. Ferritins isolated from the hearts and pancreases of β-thal/HbE subjects were found to have larger, more crystalline cores than those from the β-thal/HbE livers and spleens, possibly as a consequence of the role of the heart and pancreas as long-term iron deposition sites in this iron overload pathology.

History

Publication title

Biology of Metals

Volume

4

Pagination

162-165

ISSN

0933-5854

Publisher

Springer Verlag

Place of publication

Netherlands

Rights statement

© Springer-Verlag 1991

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the health sciences

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