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Organ-specific crystalline structures of ferritin cores in β-thalassemia/hemoglobin E

Citation

St Pierre, TG and Tran, KC and Webb, J and Macey, DJ and Heywood, BR and Sparks, NH and Wade, VJ and Manna, S and Pootrakul, P, Organ-specific crystalline structures of ferritin cores in β-thalassemia/hemoglobin E, Biology of Metals, 4, (3) pp. 162-165. ISSN 0933-5854 (1991) [Refereed Article]

Copyright Statement

Springer-Verlag 1991

DOI: doi:10.1007/BF01141308

Abstract

The cores of ferritins isolated from different organs of human subjects with β-thalassemia/hemoglobin E (β-thal/HbE) disease have different size distributions and crystallinities depending on the source organ. These patients have not been treated by hypertransfusion regimen or iron chelation therapy. β-Thal/HbE spleens and livers yield ferritin cores which are less crystalline than those isolated from normal spleens and livers, reflecting the more rapid deposition of iron in the diseased state. Ferritins isolated from the hearts and pancreases of β-thal/HbE subjects were found to have larger, more crystalline cores than those from the β-thal/HbE livers and spleens, possibly as a consequence of the role of the heart and pancreas as long-term iron deposition sites in this iron overload pathology.

Item Details

Item Type:Refereed Article
Keywords:Crystallinity; Electron microscopy; Ferrihydrite; Ferritin; Thalassemia
Research Division:Medical and Health Sciences
Research Group:Medical Biochemistry and Metabolomics
Research Field:Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics)
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Medical and Health Sciences
Author:Heywood, BR (Professor Brigid Heywood)
ID Code:104368
Year Published:1991
Web of Science® Times Cited:35
Deposited By:Research Division
Deposited On:2015-11-10
Last Modified:2015-12-22
Downloads:0

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