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Two bovine models of osteogenesis imperfecta exhibit decreased apatite crystal size

Citation

Fisher, LW and Eanes, ED and Denholm, LJ and Heywood, BR and Termine, JD, Two bovine models of osteogenesis imperfecta exhibit decreased apatite crystal size, Calcified Tissue International, 40, (5) pp. 282-285. ISSN 0171-967X (1987) [Refereed Article]

Copyright Statement

Copyright 1987 Springer-Verlag New York Inc.

DOI: doi:10.1007/BF02555262

Abstract

In recent years advances have been made in detailing the changes in both collagen and noncollagenous proteins caused by a variety of mutations leading to osteogenesis imperfecta. Much less, however, is known about the mineral phase in the affected bone. In this report, we measured the crystallinity of the apatite in bovine OI bone. Line broadening of the 002 reflection (which estimates changes in the long or c axis of the crystals) and of the 310 reflection (which estimates changes in the thickness of the crystals) both show large decreases (30 and 35% respectively). Transmission electron micrograph measurements indicate that these changes were most probably a result of smaller crystals. No decrease in the ash weight of the bone was observed.

Item Details

Item Type:Refereed Article
Keywords:apatite, bone, crystal, mineral, osteogenesis imperfecta
Research Division:Chemical Sciences
Research Group:Physical Chemistry (incl. Structural)
Research Field:Structural Chemistry and Spectroscopy
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Chemical Sciences
Author:Heywood, BR (Professor Brigid Heywood)
ID Code:104346
Year Published:1987
Web of Science® Times Cited:32
Deposited By:Research Division
Deposited On:2015-11-10
Last Modified:2015-12-18
Downloads:0

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