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Non-Anticoagulant Oligosaccharides of Enoxaparin Relieve Chemical-Induced Acute Colitis


Lean, QY and Gueven, N and Eri, RD and Peterson, GM and Patel, RP, Non-Anticoagulant Oligosaccharides of Enoxaparin Relieve Chemical-Induced Acute Colitis, Advances in Medicine and Biology, Nova Science Publishers, LV Berhardt (ed), United States, pp. 87-104. ISBN 978-1-63483-988-4 (2016) [Research Book Chapter]

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Copyright 2016 Nova Science Publishers, Inc.

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Enoxaparin, a low molecular weight heparin, is commonly used for the treatment and prophylaxis of thromboembolic disorders. Apart from its anticoagulant properties, enoxaparin is known to possess anti-inflammatory activities and therefore could potentially be useful for the management of chronic inflammatory conditions. However, the clinical use of enoxaparin in inflammation is deterred by the risk of bleeding, attributed to the presence of anticoagulant oligosaccharides. It is proposed that non-anticoagulant oligosaccharides of enoxaparin are predominantly responsible for its anti-inflammatory activity. We isolated oligosaccharides of enoxaparin using ion-exchange chromatography and the anti-inflammatory potential of oligosaccharides was evaluated in a mouse model of acute colitis. Male C57BL/6 mice were administered dextran sulphate sodium through drinking water and were subsequently treated orally with oligosaccharides of enoxaparin. Compared to untreated animals, oral enoxaparin oligosaccharide-treated mice showed reduced severity of colitis. Importantly, since the oligosaccharides of enoxaparin with no or minimal anticoagulant activity were found to be responsible for this protective effect, these molecules could be developed as novel therapeutic agents for the management of ulcerative colitis.

Item Details

Item Type:Research Book Chapter
Keywords:low molecular weight heparin, enoxaparin, inflammatory bowel disease, ulcerative colitis, carbohydrate, chromatography, HPLC, inflammation
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Lean, QY (Miss Qi Lean)
UTAS Author:Gueven, N (Dr Nuri Guven)
UTAS Author:Eri, RD (Associate Professor Raj Eri)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:104274
Year Published:2016
Deposited By:Pharmacy
Deposited On:2015-11-06
Last Modified:2017-11-06

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