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Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease

Citation

Teerlink, CC and Thibodeau, SN and McDonnell, SK and Schaid, DJ and Rinckleb, A and Maier, C and Vogel, W and Cancel-Tassin, G and Egrot, C and Cussenot, O and Foulkes, WD and Giles, GG and Hopper, JL and Severi, G and Eeles, R and Easton, D and Kote-Jarai, Z and Guy, M and Cooney, KA and Ray, AM and Zuhlke, KA and Lange, EM and Fitzgerald, LM and Stanford, JL and Ostrander, EA and Wiley, KE and Isaacs, SD and Walsh, PC and Isaacs, WB and Wahlfors, T and Tammela, T and Schleutker, J and Wiklund, F and Gronberg, H and Emanuelsson, M and Carpten, J and Bailey-Wilson, J and Whittemore, AS and Oakley-Girvan, I and Hsieh, CL and Catalona, WJ and Zheng, SL and Jin, G and Lu, L and Xu, J and Camp, NJ and Cannon-Albright, LA, International Consortium for Prostate Cancer Genetics, Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease, Human Genetics, 133, (3) pp. 347-56. ISSN 0340-6717 (2014) [Refereed Article]

Copyright Statement

Springer-Verlag Berlin Heidelberg 2013

DOI: doi:10.1007/s00439-013-1384-2

Abstract

Previous GWAS studies have reported significant associations between various common SNPs and prostate cancer risk using cases unselected for family history. How these variants influence risk in familial prostate cancer is not well studied. Here, we analyzed 25 previously reported SNPs across 14 loci from prior prostate cancer GWAS. The International Consortium for Prostate Cancer Genetics (ICPCG) previously validated some of these using a family-based association method (FBAT). However, this approach suffered reduced power due to the conditional statistics implemented in FBAT. Here, we use a case-control design with an empirical analysis strategy to analyze the ICPCG resource for association between these 25 SNPs and familial prostate cancer risk. Fourteen sites contributed 12,506 samples (9,560 prostate cancer cases, 3,368 with aggressive disease, and 2,946 controls from 2,283 pedigrees). We performed association analysis with Genie software which accounts for relationships. We analyzed all familial prostate cancer cases and the subset of aggressive cases. For the familial prostate cancer phenotype, 20 of the 25 SNPs were at least nominally associated with prostate cancer and 16 remained significant after multiple testing correction (p ≤ 1E (-3)) occurring on chromosomal bands 6q25, 7p15, 8q24, 10q11, 11q13, 17q12, 17q24, and Xp11. For aggressive disease, 16 of the SNPs had at least nominal evidence and 8 were statistically significant including 2p15. The results indicate that the majority of common, low-risk alleles identified in GWAS studies for all prostate cancer also contribute risk for familial prostate cancer, and that some may contribute risk to aggressive disease.

Item Details

Item Type:Refereed Article
Keywords:Prostate Cancer ICPCG
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Cancer Genetics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
ID Code:104119
Year Published:2014
Web of Science® Times Cited:12
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-03
Last Modified:2017-11-06
Downloads:0

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