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Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG)

Citation

Jin, G and Lu, L and Cooney, KA and Ray, AM and Zuhlke, KA and Lange, EM and Cannon-Albright, LA and Camp, NJ and Teerlink, CC and Fitzgerald, LM and Stanford, JL and Wiley, KE and Isaacs, SD and Walsh, PC and Foulkes, WD and Giles, GG and Hopper, JL and Severi, G and Eeles, R and Easton, D and Kote-Jarai, Z and Guy, M and Rinckleb, A and Maier, C and Vogel, W and Cancel-Tassin, G and Egrot, C and Cussenot, O and Thibodeau, SN and McDonnell, SK and Schaid, DJ and Wiklund, F and Gronberg, H and Emanuelsson, M and Whittemore, AS and Oakley-Girvan, I and Hsieh, C-L and Wahlfors, T and Tammela, T and Schleutker, J and Catalona, WJ and Zheng, SL and Ostrander, EA and Isaacs, WB and Xu, J, International Consortium for Prostate Cancer Genetics, Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG), Human Genetics, 131, (7) pp. 1095-1103. ISSN 0340-6717 (2012) [Refereed Article]

Copyright Statement

Copyright Springer-Verlag 2011

DOI: doi:10.1007/s00439-011-1136-0

Abstract

Multiple prostate cancer (PCa) risk-related loci have been discovered by genome-wide association studies (GWAS) based on case-control designs. However, GWAS findings may be confounded by population stratification if cases and controls are inadvertently drawn from different genetic backgrounds. In addition, since these loci were identified in cases with predominantly sporadic disease, little is known about their relationships with hereditary prostate cancer (HPC). The association between seventeen reported PCa susceptibility loci was evaluated with a family-based association test using 1,979 hereditary PCa families of European descent collected by members of the International Consortium for Prostate Cancer Genetics, with a total of 5,730 affected men. The risk alleles for 8 of the 17 loci were significantly over-transmitted from parents to affected offspring, including SNPs residing in 8q24 (regions 1, 2 and 3), 10q11, 11q13, 17q12 (region 1), 17q24 and Xp11. In subgroup analyses, three loci, at 8q24 (regions 1 and 2) plus 17q12, were significantly over-transmitted in hereditary PCa families with five or more affected members, while loci at 3p12, 8q24 (region 2), 11q13, 17q12 (region 1), 17q24 and Xp11 were significantly over-transmitted in HPC families with an average age of diagnosis at 65 years or less. Our results indicate that at least a subset of PCa risk-related loci identified by case-control GWAS are also associated with disease risk in HPC families.

Item Details

Item Type:Refereed Article
Keywords:Prostate Cancer ICPCG
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Cancer Genetics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
ID Code:104107
Year Published:2012
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-03
Last Modified:2017-11-06
Downloads:0

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