Harris, JN and Bowen, DJ and Kuniyuki, A and McIntosh, L and Fitzgerald, LM and Ostrander, EA and Stanford, JL, Interest in genetic testing among affected men from hereditary prostate cancer families and their unaffected male relatives, Genetics in Medicine, 11, (5) pp. 344-55. ISSN 1098-3600 (2009) [Refereed Article]
© 2015 American College of Medical Genetics and Genomics
PURPOSE: The objective of this study was to evaluate potential sociodemographic, medical, psychosocial, and behavioral correlates of interest in genetic testing in men from hereditary prostate cancer families.
METHODS: Family members affected with prostate cancer (n = 559) and their unaffected male relatives (n = 370) completed a mailed survey. Multivariable logistic regression models were used to examine the association between potential correlates and interest in genetic testing for prostate cancer.
RESULTS: Forty-five percent of affected and 56% of unaffected men reported that they definitely would take a genetic test for prostate cancer. More affected men reported high levels of familiarity with genetic testing than unaffected men (46 vs. 25%). There were several variables that were significantly correlated with interest in either affected or unaffected men, but only age and familiarity with genetics were significant in both groups. After controlling for confounding variables, only familiarity remained a significant correlate in both groups.
CONCLUSIONS: The contrast between low levels of familiarity with genetics and high test interest among unaffected men highlights the need for increased educational efforts targeting hereditary prostate cancer families. Overall, results illuminated several novel characteristics of men from hereditary prostate cancer families that should be considered when developing future informed consent procedures or educational materials for prostate cancer genetic testing.
|Item Type:||Refereed Article|
|Keywords:||Prostate Cancer Genetic Testing|
|Research Division:||Medical and Health Sciences|
|Research Group:||Oncology and Carcinogenesis|
|Research Field:||Cancer Genetics|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cancer and Related Disorders|
|Author:||Fitzgerald, LM (Dr Liesel Fitzgerald)|
|Web of Science® Times Cited:||1|
|Deposited By:||Menzies Institute for Medical Research|
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