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Interest in genetic testing among affected men from hereditary prostate cancer families and their unaffected male relatives


Harris, JN and Bowen, DJ and Kuniyuki, A and McIntosh, L and Fitzgerald, LM and Ostrander, EA and Stanford, JL, Interest in genetic testing among affected men from hereditary prostate cancer families and their unaffected male relatives, Genetics in Medicine, 11, (5) pp. 344-55. ISSN 1098-3600 (2009) [Refereed Article]

Copyright Statement

2015 American College of Medical Genetics and Genomics

DOI: doi:10.1097/GIM.0b013e31819b2425


PURPOSE: The objective of this study was to evaluate potential sociodemographic, medical, psychosocial, and behavioral correlates of interest in genetic testing in men from hereditary prostate cancer families.

METHODS: Family members affected with prostate cancer (n = 559) and their unaffected male relatives (n = 370) completed a mailed survey. Multivariable logistic regression models were used to examine the association between potential correlates and interest in genetic testing for prostate cancer.

RESULTS: Forty-five percent of affected and 56% of unaffected men reported that they definitely would take a genetic test for prostate cancer. More affected men reported high levels of familiarity with genetic testing than unaffected men (46 vs. 25%). There were several variables that were significantly correlated with interest in either affected or unaffected men, but only age and familiarity with genetics were significant in both groups. After controlling for confounding variables, only familiarity remained a significant correlate in both groups.

CONCLUSIONS: The contrast between low levels of familiarity with genetics and high test interest among unaffected men highlights the need for increased educational efforts targeting hereditary prostate cancer families. Overall, results illuminated several novel characteristics of men from hereditary prostate cancer families that should be considered when developing future informed consent procedures or educational materials for prostate cancer genetic testing.

Item Details

Item Type:Refereed Article
Keywords:Prostate Cancer Genetic Testing
Research Division:Biomedical and Clinical Sciences
Research Group:Oncology and carcinogenesis
Research Field:Cancer genetics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
ID Code:104105
Year Published:2009
Web of Science® Times Cited:4
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-03
Last Modified:2015-12-11

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