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Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11q14

Citation

Fitzgerald, LM and McDonnell, SK and Carlson, EE and Langeberg, W and McIntosh, LM and Deutsch, K and Ostrander, EA and Schaid, DJ and Stanford, JL, Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11-q14, European Journal of Human Genetics, 18 pp. 1141-1147. ISSN 1476-5438 (2010) [Refereed Article]

Copyright Statement

Copyright 2010 Macmillan Publishers Limited. All rights reserved

DOI: doi:10.1038/ejhg.2010.49

Abstract

The search for susceptibility loci in hereditary prostate cancer (HPC) is challenging because of locus and disease heterogeneity. One approach to reduce disease heterogeneity is to stratify families on the basis of the occurrence of multiple cancer types. This method may increase the power for detecting susceptibility loci, including those with pleiotropic effects. We have completed a genome-wide SNP linkage analysis of 96 HPC families, each of which has one or more first-degree relatives with colon cancer (CCa), and further analyzed the subset of families with two or more CCa cases (n27). When only a prostate cancer (PCa) phenotype was considered to be affected, we observed suggestive evidence for linkage (LOD Z1.86) at 15q14, 18q21 and 19q13 in all families, and at 1p32 and 15q11q14 in families with two or more CCa cases. When both the PCa and CCa phenotypes were considered affected, suggestive evidence for linkage was observed at 11q25, 15q14 and 18q21 in all families, and at 1q31, 11q14 and 15q1114 in families with two or more CCa cases. The strongest linkage signal was identified at 15q14 when both PCa and CCa phenotypes were considered to be affected in families with two or more CCa cases (recessive HLOD3.88). These results provide further support for the presence of HPC susceptibility loci on chromosomes 11q14, 15q11q14 and 19q13 and highlight loci at 1q31, 11q, 15q1114 and 18q21 as having possible pleiotropic effects. This study shows the benefit of using a comprehensive family cancer history to create more genetically homogenous subsets of HPC families for linkage analyses.

Item Details

Item Type:Refereed Article
Keywords:Prostate Cancer Linkage Analysis
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Cancer Genetics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
ID Code:104101
Year Published:2010
Web of Science® Times Cited:6
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-03
Last Modified:2015-12-11
Downloads:0

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