University of Tasmania
Browse

File(s) under permanent embargo

Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11–q14

journal contribution
posted on 2023-05-18, 13:58 authored by Liesel FitzgeraldLiesel Fitzgerald, McDonnell, SK, Carlson, EE, Langeberg, W, McIntosh, LM, Deutsch, K, Ostrander, EA, Schaid, DJ, Stanford, JL
The search for susceptibility loci in hereditary prostate cancer (HPC) is challenging because of locus and disease heterogeneity. One approach to reduce disease heterogeneity is to stratify families on the basis of the occurrence of multiple cancer types. This method may increase the power for detecting susceptibility loci, including those with pleiotropic effects. We have completed a genome-wide SNP linkage analysis of 96 HPC families, each of which has one or more first-degree relatives with colon cancer (CCa), and further analyzed the subset of families with two or more CCa cases (n¼27). When only a prostate cancer (PCa) phenotype was considered to be affected, we observed suggestive evidence for linkage (LOD Z1.86) at 15q14, 18q21 and 19q13 in all families, and at 1p32 and 15q11–q14 in families with two or more CCa cases. When both the PCa and CCa phenotypes were considered affected, suggestive evidence for linkage was observed at 11q25, 15q14 and 18q21 in all families, and at 1q31, 11q14 and 15q11–14 in families with two or more CCa cases. The strongest linkage signal was identified at 15q14 when both PCa and CCa phenotypes were considered to be affected in families with two or more CCa cases (recessive HLOD¼3.88). These results provide further support for the presence of HPC susceptibility loci on chromosomes 11q14, 15q11–q14 and 19q13 and highlight loci at 1q31, 11q, 15q11–14 and 18q21 as having possible pleiotropic effects. This study shows the benefit of using a comprehensive family cancer history to create more genetically homogenous subsets of HPC families for linkage analyses.

History

Publication title

European Journal of Human Genetics

Volume

18

Pagination

1141-1147

ISSN

1476-5438

Department/School

Menzies Institute for Medical Research

Publisher

Nature Publishing Group

Place of publication

United Kingdom

Rights statement

Copyright 2010 Macmillan Publishers Limited. All rights reserved

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Categories

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC