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Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis

Citation

Fitzgerald, LM and Karlins, E and Karyadi, DM and Kwon, EM and Koopmeiners, JS and Stanford, JL and Ostrander, EA, Association of FGFR4 genetic polymorphisms with prostate cancer risk and prognosis, Prostate Cancer and Prostatic Diseases, 12, (2) pp. 192-7. ISSN 1365-7852 (2009) [Refereed Article]

Copyright Statement

Copyright 2009 Nature Publishing Group All rights reserved

DOI: doi:10.1038/pcan.2008.46

Abstract

The fibroblast growth factor receptor 4 (FGFR4) is thought to be involved in many critical cellular processes and has been associated with prostate cancer risk. Four single nucleotide polymorphisms (SNPs) within or near FGFR4 were analyzed in a population-based study of 1458 prostate cancer patients and 1352 age-matched controls. We found no evidence to suggest that any of the FGFR4 SNP genotypes were associated with prostate cancer risk or with disease aggressiveness, Gleason score or stage. A weak association was seen between rs351855 and prostate cancer-specific mortality. Subset analysis of cases that had undergone radical prostatectomy revealed an association between rs351855 and prostate cancer risk. Although our results confirm an association between FGFR4 and prostate cancer risk in radical prostatectomy cases, they suggest that the role of FGFR4 in disease risk and outcomes at a population-based level appears to be minor.

Item Details

Item Type:Refereed Article
Keywords:Prostate Cancer
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Cancer Genetics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
ID Code:104098
Year Published:2009
Web of Science® Times Cited:18
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-03
Last Modified:2015-12-11
Downloads:0

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