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Effect of MELANOTAN1, [Nle4 , D-Phe7 ]-a-MSH, on melanin synthesis in humans with MC1R variant alleles

Citation

Fitzgerald, LM and Fryer, JL and Dwyer, T and Humphrey, SM, Effect of MELANOTAN1, [Nle4 , D-Phe7 ]-a-MSH, on melanin synthesis in humans with MC1R variant alleles, Peptides, 27, (2) pp. 388-94. ISSN 0196-9781 (2006) [Refereed Article]

Copyright Statement

Copyright 2005 Elsevier Inc. All rights reserved.

DOI: doi:10.1016/j.peptides.2004.12.038

Abstract

MELANOTAN (NDP-MSH) binds the MC1 receptor to significantly increase the eumelanin content of human skin cells. In this study of 77 Caucasian individuals, we investigated the effects of MELANOTAN in individuals with variant MC1R genotypes, as it has been suggested through in vitro studies that variant alleles decrease MELANOTAN binding efficacy, which would subsequently affect the synthesis of melanin. Administration of MELANOTAN produced a significant (p<0.001) increase in melanin density in treated, compared to placebo, individuals. Importantly, MELANOTAN increased the melanin density to a greater extent in individuals carrying the variant alleles Val60Leu, Asp84Glu, Val92Met, Arg142His, Arg151Cys, and Arg160Trp than in individuals with no variant alleles. This study demonstrates that MELANOTAN effectively increases the melanin content of skin in those individuals with MC1R variant alleles and therefore, those most in need of photoprotection.

Item Details

Item Type:Refereed Article
Keywords:MCIR Melanotan
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Cancer Genetics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
Author:Fryer, JL (Ms Jayne Fryer)
Author:Dwyer, T (Professor Terry Dwyer)
ID Code:104096
Year Published:2006
Web of Science® Times Cited:26
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-03
Last Modified:2015-12-11
Downloads:0

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