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Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

Citation

Eeles, RA and Al Olama, AA and Benlloch, S and Saunders, EJ and Leongamornlert, DA and Tymrakiewicz, M and Ghoussaini, M and Luccarini, C and Dennis, J and Jugurnauth-Little, S and Dadaev, T and Neal, DE and Hamdy, FC and Donovan, JL and Muir, K and Giles, GG and Severi, G and Wiklund, F and Gronberg, H and Haiman, CA and Schumacher, F and Henderson, BE and Le Marchand, L and Lindstrom, S and Kraft, P and Hunter, DJ and Gapstur, S and Chanock, SJ and Berndt, SJ and Albanes, D and Andriole, G and Schleutker, J and Weischer, M and Canzian, F and Riboli, E and Key, TJ and Travis, RC and Campa, D and Ingles, SA and John, EM and Hayes, RB and Pharoah, PDP and Pashayan, N and Khaw, K-T and Stanford, JL and Ostrander, EA and Signorello, LB and Thibodeau, SN and Schaid, D and Maier, C and Vogel, W and Kibel, AS and Cybulski, C and Lubinski, J and Cannon-Albright, L and Brenner, H and Park, JY and Kaneva, R and Batra, J and Spurdle, AB and Clements, JA and Teixeira, MR and Dicks, E and Lee, A and Dunning, AM and Baynes, C and Conroy, D and Maranian, MJ and Ahmed, S and Govindasami, K and Guy, M and Wilkinson, RA and Sawyer, EJ and Morgan, A and Dearnaley, DP and Horwich, A and Huddart, RA and Khoo, VS and Parker, CC and Van As, NJ and Woodhouse, CJ and Thompson, A and Dudderidge, T and Ogden, C and Cooper, CS and Lophatananon, A and Cox, A and Southey, MC and Hopper, JL and English, DR and Aly, M and Adolfsson, J and Xu, J and Zheng, SL and Yeager, M and Kaaks, R and Diver, WR and Gaudet, MM and Stern, MC and Corral, R and Joshi, AD and Shahabi, A and Wahlfors, T and Tammela, TLJ and Auvinen, A and Virtamo, J and Klarskov, P and Nordestgaard, BG and Roder, MA and Nielsen, SF and Bojesen, SE and Siddiq, A and Fitzgerald, LM and Kolb, S and Kwon, EM and Karyadi, DM and Blot, WJ and Zheng, W and Cai, Q and McDonnell, SK and Rinckleb, AE and Drake, B and Colditz, G and Wokolorczyk, D and Stephenson, RA and Teerlink, C and Muller, H and Rothenbacher, D and Sellers, TA and Lin, H-Y and Slavov, C and Mitev, V and Lose, F and Srinivasan, S and Maia, S and Paulo, P and Lange, E and Cooney, KA and Antoniou, AC and Vincent, D and Bacot, F and Tessier, DC and Kote-Jarai, Z and Easton, DF, Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array, Nature Genetics, 45, (4) pp. 385-391. ISSN 1061-4036 (2015) [Refereed Article]

Copyright Statement

2013 Nature America, Inc. All rights reserved.

DOI: doi:10.1038/ng.2560

Abstract

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 10(-8)). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

Item Details

Item Type:Refereed Article
Keywords:Prostate Cancer GWAS
Research Division:Medical and Health Sciences
Research Group:Oncology and Carcinogenesis
Research Field:Cancer Genetics
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cancer and Related Disorders
Author:Fitzgerald, LM (Dr Liesel Fitzgerald)
ID Code:104095
Year Published:2015 (online first 2013)
Web of Science® Times Cited:270
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-11-03
Last Modified:2017-11-06
Downloads:0

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