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Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

journal contribution
posted on 2023-05-18, 13:57 authored by Eeles, RA, Al Olama, AA, Benlloch, S, Saunders, EJ, Leongamornlert, DA, Tymrakiewicz, M, Ghoussaini, M, Luccarini, C, Dennis, J, Jugurnauth-Little, S, Dadaev, T, Neal, DE, Hamdy, FC, Donovan, JL, Muir, K, Giles, GG, Severi, G, Wiklund, F, Gronberg, H, Haiman, CA, Schumacher, F, Henderson, BE, Le Marchand, L, Lindstrom, S, Kraft, P, Hunter, DJ, Gapstur, S, Chanock, SJ, Berndt, SJ, Albanes, D, Andriole, G, Schleutker, J, Weischer, M, Canzian, F, Riboli, E, Key, TJ, Travis, RC, Campa, D, Ingles, SA, John, EM, Hayes, RB, Pharoah, PDP, Pashayan, N, Khaw, K-T, Stanford, JL, Ostrander, EA, Signorello, LB, Thibodeau, SN, Schaid, D, Maier, C, Vogel, W, Kibel, AS, Cybulski, C, Lubinski, J, Cannon-Albright, L, Brenner, H, Park, JY, Kaneva, R, Batra, J, Spurdle, AB, Clements, JA, Teixeira, MR, Dicks, E, Lee, A, Dunning, AM, Baynes, C, Conroy, D, Maranian, MJ, Ahmed, S, Govindasami, K, Guy, M, Wilkinson, RA, Sawyer, EJ, Morgan, A, Dearnaley, DP, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Van As, NJ, Woodhouse, CJ, Thompson, A, Dudderidge, T, Ogden, C, Cooper, CS, Lophatananon, A, Cox, A, Southey, MC, Hopper, JL, English, DR, Aly, M, Adolfsson, J, Xu, J, Zheng, SL, Yeager, M, Kaaks, R, Diver, WR, Gaudet, MM, Stern, MC, Corral, R, Joshi, AD, Shahabi, A, Wahlfors, T, Tammela, TLJ, Auvinen, A, Virtamo, J, Klarskov, P, Nordestgaard, BG, Roder, MA, Nielsen, SF, Bojesen, SE, Siddiq, A, Liesel FitzgeraldLiesel Fitzgerald, Kolb, S, Kwon, EM, Karyadi, DM, Blot, WJ, Zheng, W, Cai, Q, McDonnell, SK, Rinckleb, AE, Drake, B, Colditz, G, Wokolorczyk, D, Stephenson, RA, Teerlink, C, Muller, H, Rothenbacher, D, Sellers, TA, Lin, H-Y, Slavov, C, Mitev, V, Lose, F, Srinivasan, S, Maia, S, Paulo, P, Lange, E, Cooney, KA, Antoniou, AC, Vincent, D, Bacot, F, Tessier, DC, Kote-Jarai, Z, Easton, DF
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10(-8)). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

History

Publication title

Nature Genetics

Volume

45

Issue

4

Pagination

385-391

ISSN

1061-4036

Department/School

Menzies Institute for Medical Research

Publisher

Nature Publishing Group

Place of publication

345 Park Ave South, New York, USA, Ny, 10010-1707

Rights statement

© 2013 Nature America, Inc. All rights reserved.

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

    Categories

    Keywords

    Prostate Cancer GWAS

    Licence

    In Copyright

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