Wang, K and Xu, J and Hunter, DJ and Ding, C, Investigational drugs for the treatment of osteoarthritis, Expert Opinion on Investigational Drugs, 24, (12) pp. 1-18. ISSN 1354-3784 (2015) [Refereed Article]
Copyright 2015 Informa UK
Introduction: Osteoarthritis (OA) is a common joint disease with multiple pathophysiological processes, affecting the whole joint. Current therapeutic options such as NSAIDs can provide a palliative effect on symptoms but have limited effect on disease progression. New drugs targeting OA structures may retard disease progression at an earlier stage and delay the need for joint replacement.
Areas covered: Some drugs have entered into clinical trials and a few, such as strontium ranelate, do have improvements in both pain and structure changes. However, most of them have failed in clinical trials largely due to increased side effects or the failure to identify the right OA phenotype for the right drug in clinical design. This review describes various investigational drugs developed for the treatment of OA covering those at stages from preclinical experiments to early phase clinical trials. They include drugs for slowing cartilage degradation, regulating cartilage metabolism, targeting subchondral bone, controlling inflammation and relieving pain.
Expert opinion: Treatment options for OA remain limited. However, with the emergence of sensitive tools to detect early disease progression and identification of different OA phenotypes, disease-modifying anti-OA drugs with increased benefit and reduced risks will become available for OA treatment in the near future.
|Item Type:||Refereed Article|
|Keywords:||ADAMTS, MMP inhibitors, calcitonin, fibroblast growth factor, inflammation, osteoarthritis, pain, subchondral bone, therapy|
|Research Division:||Medical and Health Sciences|
|Research Group:||Clinical Sciences|
|Research Field:||Rheumatology and Arthritis|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Skeletal System and Disorders (incl. Arthritis)|
|Author:||Ding, C (Professor Chang-Hai Ding)|
|Web of Science® Times Cited:||15|
|Deposited By:||Menzies Institute for Medical Research|
Repository Staff Only: item control page