Wu, F and Laslett, LL and Zhang, Q, Threshold effects of vitamin D status on bone health in Chinese adolescents with low calcium intake, Journal of Clinical Endocrinology and Metabolism, 100, (12) pp. 4481-4489. ISSN 1945-7197 (2015) [Refereed Article]
© 2015 by the Endocrine Society
Context: There is no consensus on the definition of vitamin D deficiency for bone health based on serum 25-hydroxyvitamin D (25OHD) levels.
Objective: To determine whether thresholds exist for associations between25OHDlevels and bone outcomes, below which low 25OHD levels have adverse effects on bone health.
Design: Cross-sectional study.
Setting: Secondary school students in Beijing, China, aged 12–15 years.
Outcome: Measures and Participants: Serum 25OHD, bone mineral density (BMD) of total body, hipand lumbar spine (LS), serum parathyroid hormone (PTH), bone alkaline phosphatase (BAP) andtartrate-resistant acid phosphatase 5b (TRAP5b) in 222 healthy adolescents, (111 girls, 111 boys).
Results: Prevalence of low 25OHD was 61% (< 30 nmol/L) and 97% (< 50 nmol/L) (mean 25OHD = 30 nmol/L). Dietary calcium intake was low (294 and 307 mg/d for boys and girls, respectively). In girls,break-points for 25OHD (nmol/L) were: total body BMD 20 (95%CI: 14–27), hip BMD 25 (17–34), LS BMD 22 (14–30), TRAP5b 37 (22–52), and PTH 31 (23–38). In boys: total body BMD 39 (24–55), TRAP5b 33 (20–45), PTH 35 (27–43); no break-points were identified for hip and LS BMD. No break-points were identified for BAP in either gender. Below these break-points, greater 25OHD is associated with increased total body BMD, reduced PTH and TRAP5b, while above them, no such relationship exists.
Conclusions: Vitamin D deficiency and insufficiency is common in healthy Chinese adolescents. Attaining serum 25OHD levels of > 20–37 nmol/L in girls and 33–39 nmol/L in boys had positive influences on BMD and bone remodelling markers. However, estimates may be affected by low calcium intake and low serum 25OHD levels with 97% < 50 nmol/L.
|Item Type:||Refereed Article|
|Keywords:||vitamin D, dietary calcium, adolescents|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Research Field:||Rheumatology and arthritis|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Wu, F (Dr Feitong Wu)|
|UTAS Author:||Laslett, LL (Dr Laura Laslett)|
|Funding Support:||National Health and Medical Research Council (1070586)|
|Web of Science® Times Cited:||7|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||193 View Download Statistics|
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