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Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study

Citation

Hoare, S and Lithander, F and van der Mei, I and Ponsonby, A-L and Lucas, R and Taylor, B, for the Ausimmune Investigator Group, Higher intake of omega-3 polyunsaturated fatty acids is associated with a decreased risk of a first clinical diagnosis of central nervous system demyelination: Results from the Ausimmune Study, Multiple Sclerosis, 22, (7) pp. 884-892. ISSN 1352-4585 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 The Author(s)

DOI: doi:10.1177/1352458515604380

Abstract

Background: There is contradictory evidence for a role of dietary fat in risk of multiple sclerosis (MS).

Objectives: To examine the association between usual fat intake (total, saturated, monounsaturated (MUFA), polyunsaturated (PUFA), omega-3 and omega-6) and risk of a first clinical diagnosis of CNS demyelination (FCD).

Methods: Multi-centre incident case-control study in four regions of Australia during 2003-2006. Cases were aged 18-59 years and had a FCD; controls were matched to a case on age, sex and location. Dietary data were collected using a validated food frequency questionnaire.

Results: In 267 cases and 517 controls with dietary data, higher intake (per g/day) of omega-3 PUFA (adjusted odds ratio, AOR = 0.61 (95% CI 0.40-0.93)), and particularly that derived from fish (AOR = 0.54 (95% CI 0.31-0.93)) rather than from plants (AOR = 0.75 (95% CI 0.39-1.43)) was associated with a decreased risk of FCD. Total fat intake and intake of other types of fat were not associated with FCD risk.

Conclusions: There was a significant decrease in FCD risk with higher intake of omega-3 PUFA, particularly that originating from fish. There was no evidence to indicate that the intake of other types of dietary fat or fat quantity in the previous 12 months was associated with an altered risk of FCD.

Item Details

Item Type:Refereed Article
Keywords:multiple sclerosis, diet, fat, first demyelinating event, monounsaturated fat, omega-3 fatty acids, polyunsaturated fat, saturated fat
Research Division:Medical and Health Sciences
Research Group:Neurosciences
Research Field:Central Nervous System
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Nervous System and Disorders
Author:van der Mei, I (Associate Professor Ingrid van der Mei)
Author:Taylor, B (Professor Bruce Taylor)
ID Code:103415
Year Published:2015
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-10-08
Last Modified:2017-11-06
Downloads:0

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