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Neurological soft signs in schizophrenia: investigating motor overflow
journal contribution
posted on 2023-05-18, 13:23 authored by Hoy, KE, Georgiou-Karistianis, N, Maree Farrow, Fitzgerald, PBInvestigation of neurological soft signs (NSSs) in schizophrenia may allow for a greater understanding of its underlying pathology. Motor overflow, involuntary movement occurring during voluntary movement, is a NSS thought to occur to a greater degree in schizophrenia. The aim of the current study was to replicate the only objective investigation which found enhanced motor overflow in schizophrenia and to further characterise its properties in a more systematic manner than previous research. The current study involved examining motor overflow production in 30 participants (15 with schizophrenia, 15 controls). Participants exerted 25 and 75% of their maximal force output, while overflow was monitored in the passive hand using linear variable differential transformer (LVDT) units. Patients with schizophrenia not only exhibited a significantly greater degree of motor overflow, compared to controls, they also exhibited a differential pattern of overflow production. Direct investigation of the cortical processes leading to motor overflow may provide a more complete understanding of the pathological relevance of motor overflow, and by extension NSSs, in schizophrenia.
History
Publication title
World Journal of Biological PsychiatryVolume
10Issue
4 Pt.3Pagination
763-71ISSN
1562-2975Department/School
Wicking Dementia Research Education CentrePublisher
W F S B P-World Federation Socbiological PsychiatryPlace of publication
ScotlandRepository Status
- Restricted