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Neurological soft signs in schizophrenia: investigating motor overflow


Hoy, KE and Georgiou-Karistianis, N and Farrow, M and Fitzgerald, PB, Neurological soft signs in schizophrenia: investigating motor overflow, World Journal of Biological Psychiatry, 10, (4 Pt.3) pp. 763-71. ISSN 1562-2975 (2009) [Refereed Article]

DOI: doi:10.1080/15622970802562793


Investigation of neurological soft signs (NSSs) in schizophrenia may allow for a greater understanding of its underlying pathology. Motor overflow, involuntary movement occurring during voluntary movement, is a NSS thought to occur to a greater degree in schizophrenia. The aim of the current study was to replicate the only objective investigation which found enhanced motor overflow in schizophrenia and to further characterise its properties in a more systematic manner than previous research. The current study involved examining motor overflow production in 30 participants (15 with schizophrenia, 15 controls). Participants exerted 25 and 75% of their maximal force output, while overflow was monitored in the passive hand using linear variable differential transformer (LVDT) units. Patients with schizophrenia not only exhibited a significantly greater degree of motor overflow, compared to controls, they also exhibited a differential pattern of overflow production. Direct investigation of the cortical processes leading to motor overflow may provide a more complete understanding of the pathological relevance of motor overflow, and by extension NSSs, in schizophrenia.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Farrow, M (Dr Maree Farrow)
ID Code:103392
Year Published:2009
Web of Science® Times Cited:6
Deposited By:Wicking Dementia Research and Education Centre
Deposited On:2015-10-07
Last Modified:2015-10-07

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