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Infection-related hospitalization in childhood and adult metabolic outcomes

Citation

Burgner, DP and Sabin, MA and Magnussen, CG and Cheung, M and Kahonen, M and Lehtimaki, T and Hutri-Kahonen, N and Jokinen, E and Laitinen, T and Taittonen, L and Tossavainen, P and Dwyer, T and Viikari, JSA and Raitakari, OT and Juonala, M, Infection-related hospitalization in childhood and adult metabolic outcomes, Pediatrics, 136, (3) pp. e554-e562. ISSN 0031-4005 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 American Academy of Pediatrics

DOI: doi:10.1542/peds.2015-0825

Abstract

Background and Objectives: Identifying childhood determinants of adult cardiometabolic disease would facilitate early-life interventions. There are few longitudinal data on the contribution of childhood infections. Therefore, we investigated whether hospitalization with childhood infection is associated with adult anthropometric and metabolic outcomes in a large, wellphenotyped longitudinal cohort.

Methods: A total of 1376 subjects from the Cardiovascular Risk in Young Finns Study, aged 3 to 9 years at baseline (1980), who had lifetime data from birth onward on infection-related hospitalization (IRH) had repeated assessments through childhood and adolescence and at least once in adulthood (age 30-45 years in 2001-2011). Early childhood (<5 years), childhood/adolescence (5-18 years), adult (>18 years), and total lifetime IRHs were related to adiposity, BMI, and metabolic syndrome in adulthood. Analyses were adjusted for childhood and adulthood risk factors and potential confounders.

Results: Early-childhood IRH correlated with adverse adult but not childhood metabolic variables: increased BMI (P=.02) and metabolic syndrome (risk ratio: 1.56; 95% confidence interval: 1.03-2.35; P=.03), adjusted for age, gender, birth weight, childhood BMI and other risk factors, and family income. The age at which differences in adult BMI became persistent was related to age of IRH in childhood. The greatest increase in adult BMI occurred in those with >1 childhood IRH.

Conclusions: Childhood IRH was independently associated with adverse adult metabolic variables. This finding suggests that infections and/or their treatment in childhood may contribute to causal pathways leading to adult cardiometabolic diseases.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Public Health and Health Services
Research Field:Epidemiology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Cardiovascular System and Diseases
UTAS Author:Magnussen, CG (Dr Costan Magnussen)
ID Code:103145
Year Published:2015
Web of Science® Times Cited:11
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-09-23
Last Modified:2017-11-04
Downloads:0

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