Kelly, RK and Thomson, R and Smith, KJ and Dwyer, T and Venn, A and Magnussen, CG, Factors affecting tracking of blood pressure from childhood to adulthood: the Childhood Determinants of Adult Health Study, Journal of Pediatrics, 167, (6) pp. 1422-1428. ISSN 0022-3476 (2015) [Refereed Article]
Copyright 2015 Elsevier Inc. All rights reserved.
Objectives: To examine the modifiable factors that alter the trajectory of blood pressure (BP) from childhood to adulthood.
Study design: This study investigated the BP of 798 participants (53% female) from the Childhood Determinants of Adult Health Study who had BP measured when aged 9, 12, or 15 years, and at follow-up 20 years later. BP was classified as normal or elevated (prehypertensive or hypertensive) in childhood and adulthood. BP trajectory groups (persistently normal, resolution, incident elevated, persistently elevated) were established according to these classifications. Potentially modifiable factors measured at both examinations included body mass index, fruit and vegetable intake, physical activity, cardiorespiratory fitness, alcohol consumption, smoking, and socioeconomic status.
Results: Spearman correlation coefficients for BP tracking from childhood to adulthood were 0.31 (P < .001) for systolic BP and 0.16 (P < .001) for diastolic BP. Children with elevated BP had a 35% increased risk of elevated BP in adulthood compared with those with normal BP (relative risk 1.35, 95% CI 1.18-1.55, P < .001). Relative to those with persistently elevated BP, participants in the resolution group significantly decreased their body mass index z-score, decreased their alcohol consumption z-score, and increased their vegetable consumption z-score between childhood and adulthood. The proportion of participants with upwardly mobile socioeconomic status was significantly higher in the resolution group (41.2%) compared with the persistently elevated group (27.5%).
Conclusions: Resolution of elevated BP in the transition from childhood to adulthood appeared to be partially determined by modifiable factors associated with a healthy lifestyle.
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Public Health and Health Services|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Kelly, RK (Ms Rebecca Kelly)|
|Author:||Thomson, R (Dr Russell Thomson)|
|Author:||Smith, KJ (Dr Kylie Smith)|
|Author:||Dwyer, T (Professor Terry Dwyer)|
|Author:||Venn, A (Professor Alison Venn)|
|Author:||Magnussen, CG (Dr Costan Magnussen)|
|Web of Science® Times Cited:||11|
|Deposited By:||Menzies Institute for Medical Research|
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