Nikolic, SB and Edwards, LM and Karpievitch, YV and Wilson, R and Horne, J and Adams, MJ and Sharman, JE, Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus, Acta Diabetologica, 53 pp. 367-375. ISSN 1432-5233 (2016) [Refereed Article]
Copyright 2015 Springer-Verlag Italia
Aims: People with type 2 diabetes mellitus (T2DM) have abnormal peripheral and central haemodynamics at rest and during exercise, probably due to metabolic perturbations, but mechanisms are unknown. We used untargeted metabolomics to determine the relationships between metabolic perturbations and haemodynamics (peripheral and central) measured at rest and during exercise.
Methods: Serum samples from 39 participants with T2DM (62 ± 9 years; 46 % male) and 39 controls (52 ± 10 years; 51 % male) were analysed by liquid chromatography-mass spectrometry, nuclear magnetic resonance spectroscopy and principal component analysis. Scores on principal components (PC) were used to assess relationships with haemodynamics including peripheral and central BP, central augmentation index (AIx) and central augmentation pressure (AP).
Results: Participants with T2DM had higher resting and exercise haemodynamics (peripheral and central BP, central AIx and central AP) compared to controls (p < 0.05). PC that comprised of a signature metabolic pattern of T2DM was independently associated with resting and exercise central AIx and central AP (p < 0.05).
Conclusions: Serum metabolic profile was associated with central, but not peripheral, haemodynamics in T2DM participants, suggesting that metabolic irregularities may explain abnormal central haemodynamics in T2DM patients.
|Item Type:||Refereed Article|
|Keywords:||metabolomics, liquid chromatography–mass spectrometry, nuclear magnetic resonance spectroscopy, blood pressure, exercise|
|Research Division:||Medical and Health Sciences|
|Research Group:||Cardiorespiratory Medicine and Haematology|
|Research Field:||Cardiology (incl. Cardiovascular Diseases)|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Cardiovascular System and Diseases|
|Author:||Nikolic, SB (Mrs Sonja Nikolic)|
|Author:||Karpievitch, YV (Dr Yuliya Karpievitch)|
|Author:||Wilson, R (Dr Richard Wilson)|
|Author:||Horne, J (Dr James Horne)|
|Author:||Adams, MJ (Dr Murray Adams)|
|Author:||Sharman, JE (Professor James Sharman)|
|Year Published:||2016 (online first 2015)|
|Deposited By:||Menzies Institute for Medical Research|
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