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Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus


Nikolic, SB and Edwards, LM and Karpievitch, YV and Wilson, R and Horne, J and Adams, MJ and Sharman, JE, Serum metabolic profile predicts adverse central haemodynamics in patients with type 2 diabetes mellitus, Acta Diabetologica, 53 pp. 367-375. ISSN 1432-5233 (2016) [Refereed Article]

Copyright Statement

Copyright 2015 Springer-Verlag Italia

DOI: doi:10.1007/s00592-015-0802-4


Aims: People with type 2 diabetes mellitus (T2DM) have abnormal peripheral and central haemodynamics at rest and during exercise, probably due to metabolic perturbations, but mechanisms are unknown. We used untargeted metabolomics to determine the relationships between metabolic perturbations and haemodynamics (peripheral and central) measured at rest and during exercise.

Methods: Serum samples from 39 participants with T2DM (62 ± 9 years; 46 % male) and 39 controls (52 ± 10 years; 51 % male) were analysed by liquid chromatography-mass spectrometry, nuclear magnetic resonance spectroscopy and principal component analysis. Scores on principal components (PC) were used to assess relationships with haemodynamics including peripheral and central BP, central augmentation index (AIx) and central augmentation pressure (AP).

Results: Participants with T2DM had higher resting and exercise haemodynamics (peripheral and central BP, central AIx and central AP) compared to controls (p < 0.05). PC that comprised of a signature metabolic pattern of T2DM was independently associated with resting and exercise central AIx and central AP (p < 0.05).

Conclusions: Serum metabolic profile was associated with central, but not peripheral, haemodynamics in T2DM participants, suggesting that metabolic irregularities may explain abnormal central haemodynamics in T2DM patients.

Item Details

Item Type:Refereed Article
Keywords:metabolomics, liquid chromatography–mass spectrometry, nuclear magnetic resonance spectroscopy, blood pressure, exercise
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Nikolic, SB (Mrs Sonja Nikolic)
UTAS Author:Karpievitch, YV (Dr Yuliya Karpievitch)
UTAS Author:Wilson, R (Dr Richard Wilson)
UTAS Author:Horne, J (Dr James Horne)
UTAS Author:Adams, MJ (Dr Murray Adams)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:103027
Year Published:2016 (online first 2015)
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-09-16
Last Modified:2017-11-03

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