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Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans
journal contribution
posted on 2023-05-18, 12:53 authored by Schmid, J, Magee, PT, Barbara HollandBarbara Holland, Zhang, N, Cannon, RD, Magee, BBThe yeast Candida albicans, a commensal colonizer and occasional pathogen of humans, has a rudimentary mating ability. However, mating is a cumbersome process that has never been observed outside the laboratory, and the population structure of the species is predominantly clonal. Here we discuss recent findings that indicate that mating ability is under selection in C. albicans, i.e. that it is a biologically relevant process. C. albicans strains can only mate after they have sustained genetic damage. We propose that the rescue of such damaged strains by mating may be the primary reason why mating ability is under selection.
History
Publication title
Current GeneticsVolume
62Pagination
81-85ISSN
0172-8083Department/School
School of Natural SciencesPublisher
SpringerPlace of publication
New York, USARights statement
Copyright 2015 Springer-Verlag Berlin HeidelbergRepository Status
- Restricted