eCite Digital Repository

Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans

Citation

Schmid, J and Magee, PT and Holland, BR and Zhang, N and Cannon, RD and Magee, BB, Last hope for the doomed? Thoughts on the importance of a parasexual cycle for the yeast Candida albicans, Current Genetics, 62, (1) pp. 81-85. ISSN 0172-8083 (2016) [Refereed Article]

Copyright Statement

Copyright 2015 Springer-Verlag Berlin Heidelberg

DOI: doi:10.1007/s00294-015-0516-8

Abstract

The yeast Candida albicans, a commensal colonizer and occasional pathogen of humans, has a rudimentary mating ability. However, mating is a cumbersome process that has never been observed outside the laboratory, and the population structure of the species is predominantly clonal. Here we discuss recent findings that indicate that mating ability is under selection in C. albicans, i.e. that it is a biologically relevant process. C. albicans strains can only mate after they have sustained genetic damage. We propose that the rescue of such damaged strains by mating may be the primary reason why mating ability is under selection.

Item Details

Item Type:Refereed Article
Keywords:Candida albicans, parasexual cycle, mating, evolution, clonality
Research Division:Biological Sciences
Research Group:Microbiology
Research Field:Microbial Genetics
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:Holland, BR (Associate Professor Barbara Holland)
ID Code:102983
Year Published:2016
Deposited By:Mathematics and Physics
Deposited On:2015-09-14
Last Modified:2017-10-31
Downloads:0

Repository Staff Only: item control page