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B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells


Azuma, T and Yao, S and Zhu, G and Flies, AS and Flies, SJ and Chen, L, B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells, Blood, 111, (7) pp. 3635-3643. ISSN 0006-4971 (2008) [Refereed Article]

Copyright Statement

Copyright 2008 The American Society of Hematology

DOI: doi:10.1182/blood-2007-11-123141


B7-H1 is an immunoglobulin-like immune suppressive molecule broadly detectable on the majority of human and rodent cancers, and its functions have been attributed to delivering an inhibitory signal to its counter-receptor programmed death-1 (PD-1) on T cells. Here we report that B7-H1 on cancer cells receives a signal from PD-1 to rapidly induce resistance against T cell-mediated killing because crippling signaling capacity of B7-H1 but not PD-1 ablates this resistance. Importantly, loss of B7-H1 signaling is accompanied by increased susceptibility to immune-mediated tumoricidal activity. In addition to resistance against T-cell destruction, B7-H1 cancer cells also become refractory to apoptosis induced by Fas ligation or the protein kinase inhibitor Staurosporine. Our study reveals a new mechanism by which cancer cells use a receptor on immune cells as a ligand to induce resistance to therapy.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Flies, AS (Dr Andy Flies)
ID Code:102798
Year Published:2008
Web of Science® Times Cited:351
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-09-07
Last Modified:2022-09-02

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