eCite Digital Repository

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

Citation

Azuma, T and Yao, S and Zhu, G and Flies, AS and Flies, SJ and Chen, L, B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells, Blood, 111, (7) pp. 3635-3643. ISSN 0006-4971 (2008) [Refereed Article]

Copyright Statement

Copyright 2008 The American Society of Hematology

DOI: doi:10.1182/blood-2007-11-123141

Abstract

B7-H1 is an immunoglobulin-like immune suppressive molecule broadly detectable on the majority of human and rodent cancers, and its functions have been attributed to delivering an inhibitory signal to its counter-receptor programmed death-1 (PD-1) on T cells. Here we report that B7-H1 on cancer cells receives a signal from PD-1 to rapidly induce resistance against T cell–mediated killing because crippling signaling capacity of B7-H1 but not PD-1 ablates this resistance. Importantly, loss of B7-H1 signaling is accompanied by increased susceptibility to immune-mediated tumoricidal activity. In addition to resistance against T-cell destruction, B7-H1 cancer cells also become refractory to apoptosis induced by Fas ligation or the protein kinase inhibitor Staurosporine. Our study reveals a new mechanism by which cancer cells use a receptor on immune cells as a ligand to induce resistance to therapy.

Item Details

Item Type:Refereed Article
Keywords:B7-H1
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Cellular Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
Author:Flies, AS (Dr Andy Flies)
ID Code:102798
Year Published:2008
Web of Science® Times Cited:199
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-09-07
Last Modified:2015-10-06
Downloads:0

Repository Staff Only: item control page