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B7-H4–deficient mice display augmented neutrophil-mediated innate immunity
Citation
Zhu, G and Augustine, MM and Azuma, T and Luo, L and Yao, S and Anand, S and Rietz, AC and Huang, J and Xu, H and Flies, AS and Tamada, K and Colonna, M and van Duersen, JMA and Chen, L, B7-H4-deficient mice display augmented neutrophil-mediated innate immunity, Blood, 113, (8) pp. 1759-1767. ISSN 0006-4971 (2008) [Refereed Article]
Copyright Statement
Copyright 2009 The American Society of Hematology
DOI: doi:10.1182/blood-2008-01-133223
Abstract
B7-H4 is an immunoglobulin superfamily
molecule and shown to be inhibitory for
T-cell responses. To explore physiologic
roles of B7-H4, we created B7-H4–
deficient (KO) mice by genetic targeting.
B7-H4KO mice are healthy and their T- and
B-cell responses to polyclonal antigens are
in normal range. However, B7-H4KO mice
are more resistant to infection by Listeria
monocytogenesthantheirlittermates.Within
3 days after infection, bacterial colonies in
livers and spleens are significantly lower
than the controls, suggesting a role of B7-H4
in enhancing innate immunity. Further studies
demonstrate that neutrophils increase in
peripheral organs of B7-H4KO mice more so
than their littermates but their bactericidal
functions remain unchanged. Augmented
innate resistance is completely dependent
on neutrophils, even in the absence of adaptive
immunity. In vitro B7-H4 inhibits the
growth of bone marrow–derived neutrophil
progenitors, suggesting an inhibitory function
of B7-H4 in neutrophil expansion. Our
results identify B7-H4 as a negative regulator
of the neutrophil response to infection
and provide a new target for manipulation of
innate immunity.
Item Details
Item Type: | Refereed Article |
---|---|
Keywords: | B7-H4 |
Research Division: | Medical and Health Sciences |
Research Group: | Immunology |
Research Field: | Cellular Immunology |
Objective Division: | Health |
Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
Objective Field: | Immune System and Allergy |
UTAS Author: | Flies, AS (Dr Andy Flies) |
ID Code: | 102797 |
Year Published: | 2008 |
Web of Science® Times Cited: | 48 |
Deposited By: | Menzies Institute for Medical Research |
Deposited On: | 2015-09-07 |
Last Modified: | 2015-10-06 |
Downloads: | 0 |
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