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Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy


Tsushima, F and Yao, S and Shin, T and Flies, AS and Xu, H and Tamada, K and Pardoll, DM and Chen, L, Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy, Blood, 110, (1) pp. 180-185. ISSN 0006-4971 (2007) [Refereed Article]

Copyright Statement

Copyright 2007 The American Society of Hematology

DOI: doi:10.1182/blood-2006-11-060087


Although self-reactive T-cell precursors can be eliminated upon recognition of self-antigen presented in the thymus, this central tolerance process is often incomplete, and additional mechanisms are required to prevent autoimmunity. Recent studies indicates that the interaction between B7-H1 and its receptor PD-1 on activated T cells plays an important role in the inhibition of T-cell responses in peripheral organs. Here, we show that, before their exit to the periphery, T cells in lymphoid organs rapidly up-regulate PD-1 upon tolerogen recognition. Ablation of the B7-H1 and PD-1 interaction when T cells are still in lymphoid organs prevents anergy. Furthermore, blockade of B7-H1 and PD-1 interaction could render anergic T cells responsive to antigen. Our results thus reveal previously unappreciated roles of B7-H1 and PD-1 interaction in the control of initiation and reversion of T-cell anergy.

Item Details

Item Type:Refereed Article
Keywords:B7-H1, PD-1, PD-L1
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Flies, AS (Dr Andy Flies)
ID Code:102795
Year Published:2007
Web of Science® Times Cited:176
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-09-07
Last Modified:2015-10-06

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