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Alcohol consumption and Parkinsonís disease risk: a review of recent findings


Bettiol, SS and Rose, TC and Hughes, CJ and Smith, LA, Alcohol consumption and Parkinson's disease risk: a review of recent findings, Journal of Parkinson's Disease, 5 pp. 425-442. ISSN 1877-7171 (2015) [Refereed Article]


Copyright Statement

Copyright 2015 Ė IOS Press and the authors. All rights reserved. Licensed under Creative Commons Attribution-NonCommercial 3.0 Australia (CC BY-NC 3.0 AU)

DOI: doi:10.3233/JPD-150533


Background: The association between Parkinsonís disease and lifestyle exposures such as smoking, coffee and alcohol consumption have been the focus of research for several decades, with varying and often conflicting results.

Objective: This paper reviews the key features of observational studies investigating the relationship between alcohol drinking and PD risk, to determine potential sources of variability between the results.

Methods: Relevant literature from 2000Ė2014 was systematically retrieved using three databases. Primary research articles were included if they reported a measure of association between quantity and frequency of alcohol intake and PD risk, and adjusted at least for the potential confounding factors of smoking and age.

Results: Sixteen articles were identified. The seven case-control studies were more likely to report a weak protective association by level of alcohol consumption compared to the studies with prospective designs. Two studies reported the relationship between heavy (harmful to health) drinking and PD. There was weak evidence that associations varied by type of alcoholic beverage. Smoking may modify the association between alcohol intake and PD risk, however, the evidence does not support the theory that a confounder (such as an addiction-avoiding personality trait) produced the inverse associations between smoking, coffee and alcohol intake and PD risk. Methodological weaknesses of the studies, including selection and recall bias, residual confounding and lack of statistical power may in part account for their differences.

Conclusion: The weak association between alcohol drinking and PD risk was found in studies at greater risk of selection and recall bias.

Item Details

Item Type:Refereed Article
Keywords:alcohol, alcoholic beverages, alcohol drinking, Parkinsonís disease, review, risk factors, case-control studies, cohort studies, epidemiologic methods, lifestyle
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Bettiol, SS (Dr Silvana Bettiol)
UTAS Author:Hughes, CJ (Dr Clarissa Hughes)
ID Code:102529
Year Published:2015
Web of Science® Times Cited:44
Deposited By:Medicine
Deposited On:2015-08-27
Last Modified:2017-11-07
Downloads:204 View Download Statistics

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