University of Tasmania
Browse
102529 journal article.pdf (262.55 kB)

Alcohol consumption and Parkinson’s disease risk: a review of recent findings

Download (262.55 kB)
journal contribution
posted on 2023-05-18, 12:30 authored by Silvana BettiolSilvana Bettiol, Rose, TC, Clarissa HughesClarissa Hughes, Smith, LA

Background: The association between Parkinson’s disease and lifestyle exposures such as smoking, coffee and alcohol consumption have been the focus of research for several decades, with varying and often conflicting results.

Objective: This paper reviews the key features of observational studies investigating the relationship between alcohol drinking and PD risk, to determine potential sources of variability between the results.

Methods: Relevant literature from 2000–2014 was systematically retrieved using three databases. Primary research articles were included if they reported a measure of association between quantity and frequency of alcohol intake and PD risk, and adjusted at least for the potential confounding factors of smoking and age.

Results: Sixteen articles were identified. The seven case-control studies were more likely to report a weak protective association by level of alcohol consumption compared to the studies with prospective designs. Two studies reported the relationship between heavy (harmful to health) drinking and PD. There was weak evidence that associations varied by type of alcoholic beverage. Smoking may modify the association between alcohol intake and PD risk, however, the evidence does not support the theory that a confounder (such as an addiction-avoiding personality trait) produced the inverse associations between smoking, coffee and alcohol intake and PD risk. Methodological weaknesses of the studies, including selection and recall bias, residual confounding and lack of statistical power may in part account for their differences.

Conclusion: The weak association between alcohol drinking and PD risk was found in studies at greater risk of selection and recall bias.

History

Publication title

Journal of Parkinson's Disease

Volume

5

Pagination

425-442

ISSN

1877-7171

Department/School

Tasmanian School of Medicine

Publisher

IOS Press

Place of publication

Netherlands

Rights statement

Copyright 2015 – IOS Press and the authors. All rights reserved. Licensed under Creative Commons Attribution-NonCommercial 3.0 Australia (CC BY-NC 3.0 AU)https://creativecommons.org/licenses/by-nc/3.0/au/

Repository Status

  • Open

Socio-economic Objectives

Other health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC