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Association between DEFB103 gene copy number variation and ankylosing spondylitis: A case-control study


Cai, G and Xia, Q and Fan, D and Li, X and Ding, N and Hu, Y and Yang, X and Liu, L and Xin, L and Wang, L and Xu, S and Xu, J and Zou, Y and Ding, C and Pan, F, Association between DEFB103 gene copy number variation and ankylosing spondylitis: A case-control study, Tissue Antigens, 86, (3) pp. 195-198. ISSN 0001-2815 (2015) [Refereed Article]

Copyright Statement

Copyright 2015 John Wiley & Sons

DOI: doi:10.1111/tan.12630


In this brief communication, we investigate the role of DEFB103 gene copy number variation (CNV) in ankylosing spondylitis (AS) susceptibility. A total of 807 Chinese individuals including 406 AS patients and 401 controls were enrolled. The DEFB103 copy number was measured by two sets of probes to obtain a stable result in a custom-by-design Multiplex AccuCopy kit (Genesky Biotechnologies Inc., Shanghai, China) based on a multiplex fluorescence competitive polymerase chain reaction (PCR) principle. The copy number of DEFB103 ranged from 2 to 6 in both AS patients and controls. Mann–Whitney U test and chi-squared test were performed to analyze the difference of DEFB103 copy number between AS patients and controls while no statistical difference has been found. We considered the copy number of DEFB103 gene may not associate with susceptibility to AS.

Item Details

Item Type:Refereed Article
Keywords:β-defensin 3, ankylosing spondylitis, copy number variation, DEFB103
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Ding, C (Professor Chang-Hai Ding)
UTAS Author:Pan, F (Professor Faming Pan)
ID Code:102496
Year Published:2015
Web of Science® Times Cited:2
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-08-25
Last Modified:2017-11-03

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