Ramdas, S and Yousaf, F and Shastri, MD and Wanandy, T and Zaidi, STR and Khandagale, M and Jose, M and Patel, RP, Stability of daptomycin in peritoneal dialysis solutions packaged in dual-compartment infusion bags, European Journal of Hospital Pharmacy, 23 pp. 57-60. ISSN 2047-9956 (2016) [Refereed Article]
Copyright 2015 The Authors
Background: Intraperitoneal daptomycin is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by vancomycin-resistant bacteria. This study investigated the stability of daptomycin in a pH-neutral PD solution.
Methods: Reconstituted solution of daptomycin was added to a total of nine PD bags to obtain a concentration of 20 mg/L and stored at 1 of 3 different temperatures: 4 or 25°C for up to 168 h or 37°C for up to 48 h. Stabilities were determined by visual inspection, pH measurement and high-performance liquid chromatography.
Results: Daptomycin retained more than 90% of its initial concentration for 120, 72 and 12 h at 4°C, 25°C and 37°C, respectively. No physical precipitation or pH change was observed during the study.
Conclusions: Daptomycin in a pH-neutral PD solution is physically and chemically stable for 120 and 12 h at 4°C and 37°C, respectively.
|Item Type:||Refereed Article|
|Keywords:||chromatography, stability, dialysis, antibiotic|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Pharmacology and pharmaceutical sciences|
|Research Field:||Pharmaceutical sciences|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Public health (excl. specific population health) not elsewhere classified|
|UTAS Author:||Ramdas, S (Mr Sagar Ramdas)|
|UTAS Author:||Yousaf, F (Miss Farzana Yousaf)|
|UTAS Author:||Shastri, MD (Mr Madhur Shastri)|
|UTAS Author:||Wanandy, T (Mr Troy Wanandy)|
|UTAS Author:||Zaidi, STR (Dr Tabish Razi Zaidi)|
|UTAS Author:||Khandagale, M (Mr Manish Khandagale)|
|UTAS Author:||Jose, M (Professor Matthew Jose)|
|UTAS Author:||Patel, RP (Dr Rahul Patel)|
|Year Published:||2016 (online first 2015)|
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