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Stability of daptomycin in peritoneal dialysis solutions packaged in dual-compartment infusion bags


Ramdas, S and Yousaf, F and Shastri, MD and Wanandy, T and Zaidi, STR and Khandagale, M and Jose, M and Patel, RP, Stability of daptomycin in peritoneal dialysis solutions packaged in dual-compartment infusion bags, European Journal of Hospital Pharmacy, 23 pp. 57-60. ISSN 2047-9956 (2016) [Refereed Article]

Copyright Statement

Copyright 2015 The Authors

DOI: doi:10.1136/ejhpharm-2015-000651


Background: Intraperitoneal daptomycin is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by vancomycin-resistant bacteria. This study investigated the stability of daptomycin in a pH-neutral PD solution.

Methods: Reconstituted solution of daptomycin was added to a total of nine PD bags to obtain a concentration of 20 mg/L and stored at 1 of 3 different temperatures: 4 or 25C for up to 168 h or 37C for up to 48 h. Stabilities were determined by visual inspection, pH measurement and high-performance liquid chromatography.

Results: Daptomycin retained more than 90% of its initial concentration for 120, 72 and 12 h at 4C, 25C and 37C, respectively. No physical precipitation or pH change was observed during the study.

Conclusions: Daptomycin in a pH-neutral PD solution is physically and chemically stable for 120 and 12 h at 4C and 37C, respectively.

Item Details

Item Type:Refereed Article
Keywords:chromatography, stability, dialysis, antibiotic
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Pharmaceutical sciences
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Public health (excl. specific population health) not elsewhere classified
UTAS Author:Ramdas, S (Mr Sagar Ramdas)
UTAS Author:Yousaf, F (Miss Farzana Yousaf)
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Wanandy, T (Mr Troy Wanandy)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
UTAS Author:Khandagale, M (Mr Manish Khandagale)
UTAS Author:Jose, M (Professor Matthew Jose)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:102445
Year Published:2016 (online first 2015)
Deposited By:Pharmacy
Deposited On:2015-08-21
Last Modified:2017-11-02

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