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Heparins in ulcerative colitis: proposed and potential reasons for inconsistent clinical outcomes
Citation
Lean, QY and Gueven, N and Eri, RD and Bhatia, R and Sohal, SS and Stewart, N and Peterson, GM and Patel, RP, Heparins in ulcerative colitis: proposed and potential reasons for inconsistent clinical outcomes, Expert Review of Clinical Pharmacology, 8, (6) pp. 795-811. ISSN 1751-2433 (2015) [Refereed Article]
Copyright Statement
© 2015 Taylor & Francis
DOI: doi:10.1586/17512433.2015.1082425
Abstract
Current drug therapies for ulcerative colitis (UC) are not completely effective in managing
moderate-to-severe UC and approximately 20% of patients with severe UC require surgical
interventions. Heparins, polydisperse mixtures of non-anticoagulant and anticoagulant
oligosaccharides, are widely used as anticoagulants. However, heparins are also reported to
have anti-inflammatory properties. Unfractionated heparin was initially used in patients with
UC for the treatment of rectal microthrombi. Surprisingly, it was found to be effective in
reducing UC-associated symptoms. Since then, several pre-clinical and clinical studies have
reported promising outcomes of heparins in UC. In contrast, some controlled clinical trials
demonstrated no or only limited benefits, thus the potential of heparins for the treatment of
UC remains uncertain. This review discusses potential mechanisms of action of heparins, as
well as proposed reasons for their contradictory clinical effectiveness in the treatment of UC.
Item Details
Item Type: | Refereed Article |
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Keywords: | heparin, inflammatory bowel disease, low molecular weight heparin, mechanism, ulcerative colitis, non anticoagulant, chromatography |
Research Division: | Medical and Health Sciences |
Research Group: | Pharmacology and Pharmaceutical Sciences |
Research Field: | Pharmaceutical Sciences |
Objective Division: | Health |
Objective Group: | Public Health (excl. Specific Population Health) |
Objective Field: | Public Health (excl. Specific Population Health) not elsewhere classified |
UTAS Author: | Lean, QY (Miss Qi Lean) |
UTAS Author: | Gueven, N (Dr Nuri Guven) |
UTAS Author: | Eri, RD (Associate Professor Raj Eri) |
UTAS Author: | Sohal, SS (Dr Sukhwinder Sohal) |
UTAS Author: | Stewart, N (Dr Niall Stewart) |
UTAS Author: | Peterson, GM (Professor Gregory Peterson) |
UTAS Author: | Patel, RP (Dr Rahul Patel) |
ID Code: | 102444 |
Year Published: | 2015 |
Web of Science® Times Cited: | 3 |
Deposited By: | Pharmacy |
Deposited On: | 2015-08-21 |
Last Modified: | 2017-11-02 |
Downloads: | 0 |
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