Hadi, NR and Abdelhussein, MA and Rudha, ARM and Jamil, DA and Al-Aubaidy, HA, Simvastatin Use in Patients with Type 2 Diabetes Mellitus: The Effects on Oxidative Stress, Oman Medical Journal, 30, (4) pp. 237-240. ISSN 1999-768X (2015) [Refereed Article]
Methods: Our randomized control trial included 56 patients with T2DM and dyslipidemia. The participants were on glibenclamide (5mg/day) during the period of the study. The patients were divided into two study groups (groups 1 and 2). Group 1 was the control group and consisted of 31 patients. Group 2 consisted of 25 participants, who were given simvastatin 20mg tablet once daily for 12 weeks. The control group did not receive simvastatin. Both groups were followed-up for measurement of blood pressure, pulse rate, serum lipids, and parameters of oxidative stress.
Results: The simvastatin treated group showed a significant improvement with reduced erythrocyte glutathione compared to the control group (p < 0.001). This was also associated with a significant reduction in erythrocyte malondialdehyde in the simvastatin treated group compared to the control group (p < 0.001). Serum lipids reflected a similar improvement in the levels of erythrocyte malondialdehyde.
Conclusions: Our study highlights the beneficial role of simvastatin in improving the degree of oxidative stress in patients with T2DM through its effects on serum lipids and lipid peroxidation.
|Item Type:||Refereed Article|
|Keywords:||Simvastatin, Type 2 diabetes mellitus, dyslipidaemia, antioxidants|
|Research Division:||Medical and Health Sciences|
|Research Group:||Medical Biochemistry and Metabolomics|
|Research Field:||Medical Biochemistry: Carbohydrates|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|UTAS Author:||Jamil, DA (Dr Dina Jamil)|
|UTAS Author:||Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)|
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