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CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype
Citation
Zhu, Y and Zhu, G and Luo, L and Flies, AS and Chen, L, CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype, Blood, 109, (11) pp. 4882-4889. ISSN 0006-4971 (2007) [Refereed Article]
Copyright Statement
Copyright 2007 The American Society of Hematology
DOI: doi:10.1182/blood-2006-10-043463
Abstract
CD137 has long been recognized as a costimulatory receptor for growth and functional maturation of recently activated T cells in the presence of T-cell receptor signal. In this report, we present the fact that, in the absence of MHC and antigen, triggering of CD137 by an agonist monoclonal antibody induces vigorous growth of both CD8(+) and CD4(+) T cells with memory phenotype, whereas it does not affect naive T cells. Moreover, T cells with memory phenotype accumulate progressively in transgenic mice overexpressing CD137 ligand. CD137-mediated proliferation of memory T cells is directly through CD137 on T cells and does not require IL-15 and IFN-gamma. Our results define a new role of CD137 signal in the growth of memory T cells.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Immunology |
| Research Field: | Cellular immunology |
| Objective Division: | Health |
| Objective Group: | Clinical health |
| Objective Field: | Clinical health not elsewhere classified |
| UTAS Author: | Flies, AS (Dr Andy Flies) |
| ID Code: | 102359 |
| Year Published: | 2007 |
| Web of Science® Times Cited: | 67 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2015-08-16 |
| Last Modified: | 2019-05-09 |
| Downloads: | 0 |
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