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CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

Citation

Zhu, Y and Zhu, G and Luo, L and Flies, AS and Chen, L, CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype, Immunobiology: Experimental and Clinical, 109, (11) pp. 4882-4889. ISSN 0171-2985 (2007) [Refereed Article]

Copyright Statement

Copyright 2007 The American Society of Hematology

DOI: doi:10.1182/blood-2006-10- 043463

Abstract

CD137 has long been recognized as a costimulatory receptor for growth and functional maturation of recently activated T cells in the presence of T-cell receptor signal. In this report, we present the fact that, in the absence of MHC and antigen, triggering of CD137 by an agonist monoclonal antibody induces vigorous growth of both CD8 and CD4 T cells with memory phenotype, whereas it does not affect naive T cells. Moreover, T cells with memory phenotype accumulate progressively in transgenic mice overexpressing CD137 ligand. CD137-mediated proliferation of memory T cells is directly through CD137 on T cells and does not require IL-15 and IFN-. Our results de- fine a new role of CD137 signal in the growth of memory T cells. (

Item Details

Item Type:Refereed Article
Keywords:immunology
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Cellular Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
Author:Flies, AS (Dr Andy Flies)
ID Code:102359
Year Published:2007
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-08-16
Last Modified:2015-09-28
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