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CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype

journal contribution
posted on 2023-05-18, 12:20 authored by Zhu, Y, Zhu, G, Luo, L, Andrew FliesAndrew Flies, Chen, L
CD137 has long been recognized as a costimulatory receptor for growth and functional maturation of recently activated T cells in the presence of T-cell receptor signal. In this report, we present the fact that, in the absence of MHC and antigen, triggering of CD137 by an agonist monoclonal antibody induces vigorous growth of both CD8(+) and CD4(+) T cells with memory phenotype, whereas it does not affect naive T cells. Moreover, T cells with memory phenotype accumulate progressively in transgenic mice overexpressing CD137 ligand. CD137-mediated proliferation of memory T cells is directly through CD137 on T cells and does not require IL-15 and IFN-gamma. Our results define a new role of CD137 signal in the growth of memory T cells.

History

Publication title

Blood

Volume

109

Issue

11

Pagination

4882-4889

ISSN

0006-4971

Department/School

Menzies Institute for Medical Research

Publisher

Amer Soc Hematology

Place of publication

1900 M Street. Nw Suite 200, Washington, USA, Dc, 20036

Rights statement

Copyright 2007 The American Society of Hematology

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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