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CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype
Citation
Zhu, Y and Zhu, G and Luo, L and Flies, AS and Chen, L, CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype, Immunobiology: Experimental and Clinical, 109, (11) pp. 4882-4889. ISSN 0171-2985 (2007) [Refereed Article]
Copyright Statement
Copyright 2007 The American Society of Hematology
DOI: doi:10.1182/blood-2006-10- 043463
Abstract
CD137 has long been recognized as a
costimulatory receptor for growth and
functional maturation of recently activated
T cells in the presence of T-cell
receptor signal. In this report, we present
the fact that, in the absence of MHC and
antigen, triggering of CD137 by an agonist
monoclonal antibody induces vigorous
growth of both CD8 and CD4 T
cells with memory phenotype, whereas it
does not affect naive T cells. Moreover, T
cells with memory phenotype accumulate
progressively in transgenic mice overexpressing
CD137 ligand. CD137-mediated
proliferation of memory T cells is directly
through CD137 on T cells and does not
require IL-15 and IFN-. Our results de-
fine a new role of CD137 signal in the
growth of memory T cells. (
Item Details
| Item Type: | Refereed Article |
|---|---|
| Keywords: | immunology |
| Research Division: | Medical and Health Sciences |
| Research Group: | Immunology |
| Research Field: | Cellular Immunology |
| Objective Division: | Health |
| Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
| Objective Field: | Immune System and Allergy |
| Author: | Flies, AS (Dr Andy Flies) |
| ID Code: | 102359 |
| Year Published: | 2007 |
| Deposited By: | Menzies Institute for Medical Research |
| Deposited On: | 2015-08-16 |
| Last Modified: | 2015-09-28 |
| Downloads: | 0 |
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