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B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells

Citation

Luo, L and Chapoval, AL and Flies, DB and Zhu, G and Hirano, F and Wang, W and Lau, JS and Dong, H and Tamada, K and Flies, AS and Liu, Y and Chen, L, B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells, Journal of Immunology, 173, (9) pp. 5445-50. ISSN 0022-1767 (2004) [Refereed Article]

Copyright Statement

2004 by The American Association of Immunologists, Inc.

DOI: doi:10.4049/jimmunol.173.9.5445

Abstract

B7-H3 is a B7 family molecule with T cell costimulatory function in vitro. The in vivo role of B7-H3 in the stimulation of tumor immunity is unclear. We report here that expression of B7-H3 by transfection of the mouse P815 tumor line enhances its immunogenicity, leading to the regression of tumors and amplification of a tumor-specific CD8+ CTL response in syngeneic mice. Tumor cells engineered to express B7-H3 elicit a rapid clonal expansion of P1A tumor Ag-specific CD8+ CTL in lymphoid organs in vivo and acquire the ability to directly stimulate T cell growth, division, and development of cytolytic activity in vitro. Our results thus establish a role for B7-H3 in the costimulation of T cell immune responses in vivo.

Item Details

Item Type:Refereed Article
Keywords:immunology
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Cellular Immunology
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Immune System and Allergy
Author:Flies, AS (Dr Andy Flies)
ID Code:102357
Year Published:2004
Web of Science® Times Cited:106
Deposited By:Menzies Institute for Medical Research
Deposited On:2015-08-16
Last Modified:2015-09-29
Downloads:0

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