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GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters

Citation

Ramesh, SA and Tyerman, SD and Xu, B and Bose, J and Kaur, S and Conn, V and Domingos, P and Ullah, S and Wege, S and Shabala, S and Feijo, JA and Ryan, PR and Gillham, M, GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters, Nature Communications, 6 Article 7879. ISSN 2041-1723 (2015) [Refereed Article]


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Copyright 2015 Macmillan Publishers Limited.

DOI: doi:10.1038/ncomms8879

Abstract

The non-protein amino acid, gamma-aminobutyric acid (GABA) rapidly accumulates in plant tissues in response to biotic and abiotic stress, and regulates plant growth. Until now it was not known whether GABA exerts its effects in plants through the regulation of carbon metabolism or via an unidentified signalling pathway. Here, we demonstrate that anion flux through plant aluminium-activated malate transporter (ALMT) proteins is activated by anions and negatively regulated by GABA. Site-directed mutagenesis of selected amino acids within ALMT proteins abolishes GABA efficacy but does not alter other transport properties. GABA modulation of ALMT activity results in altered root growth and altered root tolerance to alkaline pH, acid pH and aluminium ions. We propose that GABA exerts its multiple physiological effects in plants via ALMT, including the regulation of pollen tube and root growth, and that GABA can finally be considered a legitimate signalling molecule in both the plant and animal kingdoms.

Item Details

Item Type:Refereed Article
Keywords:GABA, signalling, ion channel
Research Division:Biological Sciences
Research Group:Plant Biology
Research Field:Plant Physiology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Environmental Sciences
Author:Bose, J (Dr Jayakumar Bose)
Author:Shabala, S (Professor Sergey Shabala)
ID Code:102229
Year Published:2015
Web of Science® Times Cited:65
Deposited By:Tasmanian Institute of Agriculture
Deposited On:2015-08-05
Last Modified:2017-11-02
Downloads:91 View Download Statistics

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