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Metabolic fate of dietary terpenes from Eucalyptus radiata in common ringtail possum (Pseudocheirus peregrinus)

Citation

McLean, S and Foley, WJ and Davies, NW and Brandon, S and Li, D and Blackman, AJ, Metabolic fate of dietary terpenes from Eucalyptus radiata in common ringtail possum (Pseudocheirus peregrinus), Journal of Chemical Ecology, 19, (8) pp. 1625-1643. ISSN 0098-0331 (1993) [Refereed Article]

Copyright Statement

Copyright 1993 Plenum Publishing Corporation

DOI: doi:10.1007/BF00982297

Abstract

Arboreal marsupials consume terpenes in quantities that are toxic to other mammals, indicating that they possess special detoxification mechanisms. The metabolic fate of dietary terpenes was studied in the common ringtail possum (Pseudocheirus peregrinus). Three animals were fed Eucalyptus radiata leaf for 10 days. Leaf consumption increased over three days to an average steady state of about 10-15 mmol total terpenes per day. GCMS analysis identified six urinary terpene metabolites, which were dicarboxylic acids, hydroxyacids, or lactones. Another nine metabolites could only be shown to be terpene-derived but of unknown structure. The amounts excreted were estimated by GC-FID, using response factors based on carbon content. Total 24-hr excretion of terpene-derived metabolites increased to 6.2-7.6 mmol on days 5-10, while glucuronic acid excretion remained constant at about 1.5 mmol. No other conjugates of terpene metabolites were found. The strategy used by the possum to detoxify dietary terpenes seems to be to polyoxygenate the molecules forming highly polar, acidic metabolites that can be readily excreted. Conjugation is minimal, perhaps to conserve carbohydrate and amino acids.

Item Details

Item Type:Refereed Article
Keywords:terpene, possum, Pseudocheirus peregrinus, Eucalyptus radiata, metabolism, foliage, diet, urinary acids, glucuronic acid
Research Division:Biological Sciences
Research Group:Ecology
Research Field:Ecological Physiology
Objective Division:Expanding Knowledge
Objective Group:Expanding Knowledge
Objective Field:Expanding Knowledge in the Biological Sciences
Author:McLean, S (Professor Stuart McLean)
Author:Davies, NW (Associate Professor Noel Davies)
Author:Brandon, S (Mrs Susan Brandon)
Author:Li, D (Mr Duo Li)
Author:Blackman, AJ (Dr Adrian Blackman)
ID Code:102205
Year Published:1993
Web of Science® Times Cited:42
Deposited By:Central Science Laboratory
Deposited On:2015-08-04
Last Modified:2017-06-07
Downloads:0

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