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Formation of reactive metabolites of phenacetin in humans and rats
Citation
Veronese, ME and McLean, S and D'souza, C and Davies, NW, Formation of reactive metabolites of phenacetin in humans and rats, Xenobiotica, 15, (11) pp. 929-940. ISSN 0049-8254 (1985) [Refereed Article]
Copyright Statement
Copyright 1985 Taylor & Francis
DOI: doi:10.3109/00498258509045046
Abstract
1. The metabolism of phenacetin to reactive intermediates in humans was estimated from the excretion of thio adducts in urine. N-Hydroxyphenacetin, a precursor of reactive metabolites, was also quantified.
2. Following an oral dose of phenacetin (10 mg/kg) to humans, these metabolites in 24 h urine were: paracetamol-3-cysteine, 4·4% dose; paracetamol-3-mercapturate, 3·9%; 3-thiomethylparacetamol, 0·4%; N-hydroxyphenacetin, 0·5%
3. Rats showed a considerable increase in N-hydroxyphenacetin excretion after chronic dosing with phenacetin at high dosage (500 mg/kg) for one month. Chronic dosing with a low dose (50 mg/kg) did not increase N-hydroxyphenacetin excretion, but a marked increase occurred on concomitant administration of aspirin and caffeine.
Item Details
Item Type: | Refereed Article |
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Research Division: | Medical and Health Sciences |
Research Group: | Medical Biochemistry and Metabolomics |
Research Field: | Metabolic Medicine |
Objective Division: | Expanding Knowledge |
Objective Group: | Expanding Knowledge |
Objective Field: | Expanding Knowledge in the Medical and Health Sciences |
UTAS Author: | Veronese, ME (Mr Maurice Veronese) |
UTAS Author: | McLean, S (Professor Stuart McLean) |
UTAS Author: | D'souza, C (Mr Conrad D'Souza) |
UTAS Author: | Davies, NW (Associate Professor Noel Davies) |
ID Code: | 102181 |
Year Published: | 1985 |
Web of Science® Times Cited: | 23 |
Deposited By: | Central Science Laboratory |
Deposited On: | 2015-08-03 |
Last Modified: | 2015-09-22 |
Downloads: | 0 |
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