Huo, JZ and Aldous, S and Campbell, K and Davies, NW, Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat, Xenobiotica, 19, (2) pp. 161-170. ISSN 0049-8254 (1989) [Refereed Article]
Copyright 1989 Taylor & Francis Ltd
1. Single doses of 1,2,4-trimethylbenzene (124TMB) or 14C-124TMB were administered orally to rats for metabolism and distribution studies.
2. 14C-124TMB was rapidly and widely distributed throughout the body with the highest levels in adipose tissue. No other preferential uptake of 14C-124TMB by any of the organs or tissues examined was evident.
3. Tissue levels declined rapidly within 24 h after dosage, with more than 99% of the administered radioactivity recovered in the urine during this period.
4. A complex mixture of isomeric trimethylphenols, dimethylbenzyl alcohols, dimethylbenzoic acids and dimethylhippuric acids excreted in the urine accounted for more than 81% of the administered dose. The major metabolites were 3,4-dimethyl-hippuric acid (30.2% dose), 2,4-dimethylbenzylalcohol (12.7% dose, primarily as sulphate and glucuronide conjugates) and 2,5-dimethylbenzyl alcohol (11.7% dose, primarily as sulphate and glucuronide conjugates).
|Item Type:||Refereed Article|
|Research Division:||Medical and Health Sciences|
|Research Group:||Medical Biochemistry and Metabolomics|
|Research Field:||Metabolic Medicine|
|Objective Group:||Clinical Health (Organs, Diseases and Abnormal Conditions)|
|Objective Field:||Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified|
|Author:||Aldous, S (Dr Stephen Aldous)|
|Author:||Campbell, K (Ms Kathryn Claire Campbell)|
|Author:||Davies, NW (Associate Professor Noel Davies)|
|Web of Science® Times Cited:||22|
|Deposited By:||Central Science Laboratory|
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