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Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat
Citation
Huo, JZ and Aldous, S and Campbell, K and Davies, NW, Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat, Xenobiotica, 19, (2) pp. 161-170. ISSN 0049-8254 (1989) [Refereed Article]
Copyright Statement
Copyright 1989 Taylor & Francis Ltd
DOI: doi:10.3109/00498258909034688
Abstract
1. Single doses of 1,2,4-trimethylbenzene (124TMB) or 14C-124TMB were administered orally to rats for metabolism and distribution studies.
2. 14C-124TMB was rapidly and widely distributed throughout the body with the highest levels in adipose tissue. No other preferential uptake of 14C-124TMB by any of the organs or tissues examined was evident.
3. Tissue levels declined rapidly within 24 h after dosage, with more than 99% of the administered radioactivity recovered in the urine during this period.
4. A complex mixture of isomeric trimethylphenols, dimethylbenzyl alcohols, dimethylbenzoic acids and dimethylhippuric acids excreted in the urine accounted for more than 81% of the administered dose. The major metabolites were 3,4-dimethyl-hippuric acid (30.2% dose), 2,4-dimethylbenzylalcohol (12.7% dose, primarily as sulphate and glucuronide conjugates) and 2,5-dimethylbenzyl alcohol (11.7% dose, primarily as sulphate and glucuronide conjugates).
Item Details
Item Type: | Refereed Article |
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Research Division: | Medical and Health Sciences |
Research Group: | Medical Biochemistry and Metabolomics |
Research Field: | Metabolic Medicine |
Objective Division: | Health |
Objective Group: | Clinical Health (Organs, Diseases and Abnormal Conditions) |
Objective Field: | Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified |
UTAS Author: | Aldous, S (Dr Stephen Aldous) |
UTAS Author: | Campbell, K (Ms Kathryn Claire Campbell) |
UTAS Author: | Davies, NW (Associate Professor Noel Davies) |
ID Code: | 102176 |
Year Published: | 1989 |
Web of Science® Times Cited: | 22 |
Deposited By: | Central Science Laboratory |
Deposited On: | 2015-08-03 |
Last Modified: | 2015-08-10 |
Downloads: | 0 |
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