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Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat

Citation

Huo, JZ and Aldous, S and Campbell, K and Davies, NW, Distribution and metabolism of 1,2,4-trimethylbenzene (pseudocumene) in the rat, Xenobiotica, 19, (2) pp. 161-170. ISSN 0049-8254 (1989) [Refereed Article]

Copyright Statement

Copyright 1989 Taylor & Francis Ltd

DOI: doi:10.3109/00498258909034688

Abstract

1. Single doses of 1,2,4-trimethylbenzene (124TMB) or 14C-124TMB were administered orally to rats for metabolism and distribution studies.

2. 14C-124TMB was rapidly and widely distributed throughout the body with the highest levels in adipose tissue. No other preferential uptake of 14C-124TMB by any of the organs or tissues examined was evident.

3. Tissue levels declined rapidly within 24 h after dosage, with more than 99% of the administered radioactivity recovered in the urine during this period.

4. A complex mixture of isomeric trimethylphenols, dimethylbenzyl alcohols, dimethylbenzoic acids and dimethylhippuric acids excreted in the urine accounted for more than 81% of the administered dose. The major metabolites were 3,4-dimethyl-hippuric acid (30.2% dose), 2,4-dimethylbenzylalcohol (12.7% dose, primarily as sulphate and glucuronide conjugates) and 2,5-dimethylbenzyl alcohol (11.7% dose, primarily as sulphate and glucuronide conjugates).

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Medical Biochemistry and Metabolomics
Research Field:Metabolic Medicine
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
Author:Aldous, S (Dr Stephen Aldous)
Author:Campbell, K (Ms Kathryn Claire Campbell)
Author:Davies, NW (Associate Professor Noel Davies)
ID Code:102176
Year Published:1989
Web of Science® Times Cited:22
Deposited By:Central Science Laboratory
Deposited On:2015-08-03
Last Modified:2015-08-10
Downloads:0

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