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Platelet activating factor receptor: gateway for bacterial chronic airway infection in chronic obstructive pulmonary disease and potential therapeutic target

Citation

Shukla, SD and Sohal, SS and O'Toole, RF and Eapen, MS and Walters, EH, Platelet activating factor receptor: gateway for bacterial chronic airway infection in chronic obstructive pulmonary disease and potential therapeutic target, Expert Review of Respiratory Medicine, 9, (4) pp. 473-485. ISSN 1747-6348 (2015) [Refereed Article]

Copyright Statement

2015 Informa UK Ltd

DOI: doi:10.1586/17476348.2015.1070673

Abstract

The authors established that cigarette smoke increases airway epithelial platelet activating factor receptor (PAFr) expression and that PAFr is markedly up-regulated in the lungs of chronic obstructive pulmonary disease (COPD) patients. Crucially, PAFr is used by the two key bacterial species involved in chronic infection and acute exacerbations in COPD, that is, Streptococcus pneumoniae and Haemophilus influenzae,/i>, as a receptor for lung epithelial colonization. The cognate adhesin of PAFr, phosphorylcholine (ChoP), in the cell wall of these bacterial species may be a key effector that underpins host colonization. In this review, the authors evaluate the respective roles of PAFr and ChoP in the natural history of COPD and discuss the potential of the airway epithelial PAFr–bacterial ChoP interaction as a selective anti-infective target in COPD therapeutics.

Item Details

Item Type:Refereed Article
Keywords:chronic obstructive pulmonary disease
Research Division:Medical and Health Sciences
Research Group:Medical Microbiology
Research Field:Medical Bacteriology
Objective Division:Manufacturing
Objective Group:Human Pharmaceutical Products
Objective Field:Human Pharmaceutical Treatments (e.g. Antibiotics)
Author:Shukla, SD (Mr Shakti Shukla)
Author:Sohal, SS (Dr Sukhwinder Sohal)
Author:O'Toole, RF (Dr Ronan O'Toole)
Author:Eapen, MS (Mr Mathew Eapen)
Author:Walters, EH (Professor Haydn Walters)
ID Code:102080
Year Published:2015
Web of Science® Times Cited:9
Deposited By:Medicine (Discipline)
Deposited On:2015-07-27
Last Modified:2017-11-04
Downloads:0

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