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Geogenic PM10 exposure exacerbates responses to influenza infection

Citation

Clifford, HD and Perks, KL and Zosky, GR, Geogenic PM10 exposure exacerbates responses to influenza infection, Science of the Total Environment, 533 pp. 275-282. ISSN 0048-9697 (2015) [Refereed Article]

Copyright Statement

© 2015 Published by Elsevier B.V.

DOI: doi:10.1016/j.scitotenv.2015.07.001

Abstract

Particulate matter (PM) exposure has been linked epidemiologically to exacerbations of lung disease, including respiratory infections. We investigated the effects of geogenic (earth-derived) PM10 (PM < 10 μm diameter) on the response to a respiratory viral infection.

Geogenic dust was sampled from four communities in arid environments in Western Australia. Adult female BALB/c mice were intranasally exposed to chronic doses of PM10 (10 μg/day for 10 days), and/or infected with influenza (A/Mem/1/71) virus. Inflammation (cells, IL-6, IFN-γ) was measured in bronchoalveolar lavage. Lung mechanics were measured using the forced oscillation technique.

Geogenic PM10 induced lung inflammation (neutrophils, macrophages) with additive effects in mice also infected with influenza. PM10 also modified the influenza-induced IL-6 and IFN-γ responses. Geogenic PM10 increased airway resistance, and increased hysteresivity in those exposed to both insults. Viral titres were significantly higher after PM10 exposure. Iron concentration was inversely associated with IFN-γ and positively associated with viral titre and hysteresivity.

Geogenic PM10 exposure increases inflammation, impairs lung function and increases viral load, exacerbating the response to respiratory viral infection. Iron in the particles may be a driver of these responses. This has important implications for respiratory health in communities exposed to high geogenic PM10, such as those in arid environments.

Item Details

Item Type:Refereed Article
Keywords:particle, geogenic, influenza, inflammation, lung function, viral titre, iron, pm10, mouse
Research Division:Medical and Health Sciences
Research Group:Cardiorespiratory Medicine and Haematology
Research Field:Respiratory Diseases
Objective Division:Health
Objective Group:Clinical Health (Organs, Diseases and Abnormal Conditions)
Objective Field:Respiratory System and Diseases (incl. Asthma)
Author:Zosky, GR (Associate Professor Graeme Zosky)
ID Code:101943
Year Published:2015
Web of Science® Times Cited:7
Deposited By:Medicine (Discipline)
Deposited On:2015-07-19
Last Modified:2017-11-02
Downloads:0

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