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An evolution-based hypothesis on the origin and mechanisms of autoimmune disease

Citation

Boyd, GW, An evolution-based hypothesis on the origin and mechanisms of autoimmune disease, Immunology and Cell Biology, 75, (5) pp. 503-507. ISSN 0818-9641 (1997) [Refereed Article]

DOI: doi:10.1038/icb.1997.78

Abstract

The pathogenesis of autoimmune disease remains an enigma. Here, the condition is analysed from an evolutionary standpoint, and the thesis developed that viruses, in particular retroviruses, are important to our evolution, and that their inappropriate re-expression by repetitive (? ischaemic) cell damage in individuals of appropriate major histocompatibility type, leads to autoimmune disease. Such a view requires a slight adjustment to traditional ways of seeing Darwinian evolution, but one which makes real sense of the MHC-restricted nature of the adaptive immune response.

Item Details

Item Type:Refereed Article
Research Division:Medical and Health Sciences
Research Group:Immunology
Research Field:Immunology not elsewhere classified
Objective Division:Health
Objective Group:Other Health
Objective Field:Health not elsewhere classified
Author:Boyd, GW (Professor Graham Boyd)
ID Code:10188
Year Published:1997
Web of Science® Times Cited:8
Deposited By:Clinical Sciences
Deposited On:1997-08-01
Last Modified:2011-08-11
Downloads:0

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