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An evolution-based hypothesis on the origin and mechanisms of autoimmune disease
Citation
Boyd, GW, An evolution-based hypothesis on the origin and mechanisms of autoimmune disease, Immunology and Cell Biology, 75, (5) pp. 503-507. ISSN 0818-9641 (1997) [Refereed Article]
Abstract
The pathogenesis of autoimmune disease remains an enigma. Here, the condition is analysed from an evolutionary standpoint, and the thesis developed that viruses, in particular retroviruses, are important to our evolution, and that their inappropriate re-expression by repetitive (? ischaemic) cell damage in individuals of appropriate major histocompatibility type, leads to autoimmune disease. Such a view requires a slight adjustment to traditional ways of seeing Darwinian evolution, but one which makes real sense of the MHC-restricted nature of the adaptive immune response.
Item Details
| Item Type: | Refereed Article |
|---|---|
| Research Division: | Biomedical and Clinical Sciences |
| Research Group: | Immunology |
| Research Field: | Immunology not elsewhere classified |
| Objective Division: | Health |
| Objective Group: | Other health |
| Objective Field: | Other health not elsewhere classified |
| UTAS Author: | Boyd, GW (Professor Graham Boyd) |
| ID Code: | 10188 |
| Year Published: | 1997 |
| Web of Science® Times Cited: | 9 |
| Deposited By: | Clinical Sciences |
| Deposited On: | 1997-08-01 |
| Last Modified: | 2011-08-11 |
| Downloads: | 0 |
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