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Determination of nicotine in cartridge-based electronic cigarettes
journal contribution
posted on 2023-05-18, 11:47 authored by Wenying LuWenying Lu, Stuart FergusonStuart Ferguson, David NicholsDavid Nichols, Rahul PatelRahul Patel, Glenn JacobsonGlenn JacobsonElectronic cigarettes are a relatively new form of nicotine delivery and their popularity is increasing rapidly. One concern regarding the safety of electronic cigarette is quality control during their manufacture, including whether the nicotine concentration matches the labelling. An assay was developed to evaluate the concentration of nicotine in electronic cigarette cartridges. For nicotine extraction, the pad was removed from the cartridge. Deuterated nicotine solution (1 µg), used as the external standard, was added to the pad and allowed to penetrate into the matrix. The pad was treated with 50 mL of 50% (v/v) methanol/deionized water in an ultrasonic bath for fifteen minutes at ambient temperature. After sonication, the extract was further diluted with deionized water and then analyzed by ultra-high performance liquid chromatography–tandem mass spectrometry. The recovery of nicotine-d4 was 81.5 ± 3.7%. Based on the recovery, the nicotine concentration in the electronic cigarette cartridges was 11.9 ± 1.3 mg, which was lower than the labelled concentration (16 mg). The nicotine concentration did not vary significantly between cartridges within one pack or between packs. The nicotine concentration in the electronic cigarette cartridges was determined by this assay. Differences between labelled and actual nicotine concentrations may affect clinical trials.
History
Publication title
Analytical LettersVolume
48Issue
17Pagination
2715-2722ISSN
0003-2719Department/School
School of Pharmacy and PharmacologyPublisher
Marcel Dekker IncPlace of publication
United StatesRights statement
Copyright Taylor & Francis Group, LLCRepository Status
- Restricted