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Factors associated with the development of depression in chronic non-cancer pain patients following the onset of opioid treatment for pain

Citation

Smith, K and Mattick, RP and Bruno, R and Nielsen, S and Cohen, M and Campbell, G and Larance, B and Farrell, M and Degenhardt, L, Factors associated with the development of depression in chronic non-cancer pain patients following the onset of opioid treatment for pain, Journal of Affective Disorders, 184 pp. 72-80. ISSN 0165-0327 (2015) [Refereed Article]

Copyright Statement

2015 Elsevier B.V. All rights reserved.

DOI: doi:10.1016/j.jad.2015.05.049

Abstract

Background and aims: Pharmaceutical opioid prescription rates are increasing globally, however knowledge of their long-term effects on mental health, in particular depression remains limited. This study aimed to identify factors associated with the onset of depression post-opioid use that differ to factors associated with depression post-pain.

Method: Participants (N = 1418) were a national sample prescribed opioids for chronic non-cancer pain. Age at onset of depression, pain and commencement of opioid medications were collected via structured interview.

Results: Six in 10 (61%) reported lifetime depression; of those, almost half developed depression after pain and after they started opioid medications (48%). Variables associated with post-opioid depression included lower pain self-efficacy and poorer social support, younger onset of opioid use, and difficulties and concerns with opioid medications.

Conclusions: The findings highlight the importance of monitoring for the emergence of mood dysfunction, particularly for those starting opioids for pain at a younger age, and consideration of psychological treatments that address self-efficacy that appears to be associated with post-opioid depression.

Item Details

Item Type:Refereed Article
Keywords:depression, chronic pain, pharmaceutical opioids, self-efficacy
Research Division:Psychology and Cognitive Sciences
Research Group:Psychology
Research Field:Psychology not elsewhere classified
Objective Division:Health
Objective Group:Public Health (excl. Specific Population Health)
Objective Field:Substance Abuse
Author:Bruno, R (Associate Professor Raimondo Bruno)
ID Code:101841
Year Published:2015
Funding Support:National Health and Medical Research Council (APP1022522)
Web of Science® Times Cited:9
Deposited By:Psychology
Deposited On:2015-07-12
Last Modified:2017-11-07
Downloads:0

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