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Neural correlates of impaired emotional face recognition in cerebellar lesions


Adamaszek, M and Kirkby, KC and D'Agata, F and Olbrich, S and Langner, S and Steele, C and Sehm, C and Busse, S and Kessler, C and Hamm, A, Neural correlates of impaired emotional face recognition in cerebellar lesions, Brain Research, 1613 pp. 1-12. ISSN 0006-8993 (2015) [Refereed Article]

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Copyright 2015 Elsevier B.V. All rights reserved.

DOI: doi:10.1016/j.brainres.2015.01.027


Clinical and neuroimaging data indicate a cerebellar contribution to emotional processing, which may account for affective-behavioral disturbances in patients with cerebellar lesions. We studied the neurophysiology of cerebellar involvement in recognition of emotional facial expression. Participants comprised eight patients with discrete ischemic cerebellar lesions and eight control patients without any cerebrovascular stroke. Event-related potentials (ERP) were used to measure responses to faces from the Karolinska Directed Emotional Faces Database (KDEF), interspersed in a stream of images with salient contents. Images of faces augmented N170 in both groups, but increased late positive potential (LPP) only in control patients without brain lesions. Dipole anaylsis revealed altered activation patterns for negative emotions in patients with cerebellar lesions, including activation of the left inferior prefrontal area to images of faces showing fear, contralateral to controls. Correlation analysis indicated that lesions of cerebellar area Crus I contribute to ERP deviations. Overall, our results implicate the cerebellum in integrating emotional information at different higher order stages, suggesting distinct cerebellar contributions to the proposed large-scale cerebral network of emotional face recognition.

Item Details

Item Type:Refereed Article
Keywords:cerebellum, ERP, emotional facial expressions, prefrontal cortex
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Mental health services
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:Kirkby, KC (Professor Kenneth Kirkby)
ID Code:101760
Year Published:2015
Web of Science® Times Cited:37
Deposited By:Medicine
Deposited On:2015-07-07
Last Modified:2017-11-06

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