eCite Digital Repository
Neural correlates of impaired emotional face recognition in cerebellar lesions
Adamaszek, M and Kirkby, KC and D'Agata, F and Olbrich, S and Langner, S and Steele, C and Sehm, C and Busse, S and Kessler, C and Hamm, A, Neural correlates of impaired emotional face recognition in cerebellar lesions, Brain Research, 1613 pp. 1-12. ISSN 0006-8993 (2015) [Refereed Article]
Copyright 2015 Elsevier B.V. All rights reserved.
Clinical and neuroimaging data indicate a cerebellar contribution to emotional processing, which may account for affective-behavioral disturbances in patients with cerebellar lesions. We studied the neurophysiology of cerebellar involvement in recognition of emotional facial expression. Participants comprised eight patients with discrete ischemic cerebellar lesions and eight control patients without any cerebrovascular stroke. Event-related potentials (ERP) were used to measure responses to faces from the Karolinska Directed Emotional Faces Database (KDEF), interspersed in a stream of images with salient contents. Images of faces augmented N170 in both groups, but increased late positive potential (LPP) only in control patients without brain lesions. Dipole anaylsis revealed altered activation patterns for negative emotions in patients with cerebellar lesions, including activation of the left inferior prefrontal area to images of faces showing fear, contralateral to controls. Correlation analysis indicated that lesions of cerebellar area Crus I contribute to ERP deviations. Overall, our results implicate the cerebellum in integrating emotional information at different higher order stages, suggesting distinct cerebellar contributions to the proposed large-scale cerebral network of emotional face recognition.
|Item Type:||Refereed Article|
|Keywords:||cerebellum, ERP, emotional facial expressions, prefrontal cortex|
|Research Division:||Health Sciences|
|Research Group:||Health services and systems|
|Research Field:||Mental health services|
|Objective Group:||Public health (excl. specific population health)|
|Objective Field:||Mental health|
|UTAS Author:||Kirkby, KC (Professor Kenneth Kirkby)|
|Web of Science® Times Cited:||37|
Repository Staff Only: item control page